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Circular Rnas: Novel Actors of Wnt Signaling Pathway in Lung Cancer Progression Publisher



Alimohammadi M1 ; Gholinezhad Y2 ; Mousavi V3 ; Kahkesh S4 ; Rezaee M2 ; Yaghoobi A2 ; Mafi A5, 6 ; Araghi M7
Authors

Source: EXCLI Journal Published:2023


Abstract

Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer. Interactions of tumor-derived circRNAs with the Wnt/β-catenin signaling pathway provide both clinical diagnostic biomarkers and promising therapeutic targets. In this review, we outlined current evidence on the roles of circRNAs associated with the Wnt/β-catenin pathway in regulating lung cancer formation and development. We believe that our findings will assist in the advancement or establishment of circRNA-based lung cancer therapeutic approaches. © 2023, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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