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Effects of Curcuminoids on Inflammatory Status in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial Publisher Pubmed



Saberikarimian M1 ; Keshvari M2 ; Ghayourmobarhan M3, 4 ; Salehizadeh L2 ; Rahmani S5 ; Behnam B6, 7 ; Jamialahmadi T8, 9 ; Asgary S2 ; Sahebkar A10, 11, 12
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Iranian UNESCO Center of Excellence for Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Halal Research Center of IRI, FDA, Tehran, Iran
  9. 9. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Complementary Therapies in Medicine Published:2020


Abstract

Background: Nonalcoholic fatty liver diseases (NAFLD) is a highly prevalent disease that is closely associated with several cardiometabolic complications. The potential anti-inflammatory role of curcuminoids that have already been reported to reduce hepatic steatosis, in patients with NAFLD was explored in this study. Methods: This double-blind, randomized placebo-controlled trial was conducted for a period of 8 weeks in patients with NAFLD. Subjects (n = 55) were randomly allocated to receive either curcuminoids or placebo. The curcuminoids group received one capsule containing 500 mg curcuminoids (plus 5 mg piperine to increase intestinal absorption) per day for 8 weeks and the control group received matched placebo capsules for the same period. Liver ultrasonography was performed to assess the severity of hepatic steatosis at baseline and the study end. Serum levels of cytokines including interleukin-1α, interleukin-1β, interleukin-2, interleukin-4, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-α, monocyte chemoattractant protein-1, interferon γ, vascular endothelial growth factor and epidermal growth factor were measured before and after the intervention. Results: The two groups were comparable in demographic features at baseline. The results showed that supplementation with curcuminoids could decrease weight compared to the placebo group (p = 0.016) in patients with NAFLD. Curcuminoids supplementation improved the severity of NAFLD according to the ultrasound results (p = 0.002). Moreover, serum concentrations of TNF-α (p = 0.024), MCP-1 (p = 0.008) and EGF (p = 0.0001) were improved by curcuminoids in NAFLD patients. Conclusions: The results of our study showed that curcumin supplementation can improve serum levels of inflammatory cytokines in subjects with NAFLD and this might be at least partly responsible for the anti-steatotic effects of curcuminoids. © 2020 Elsevier Ltd
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