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Curcumin and Piperine in Covid-19: A Promising Duo to the Rescue? Publisher Pubmed



Miryan M1, 2 ; Soleimani D3 ; Askari G4, 5, 6 ; Jamialahmadi T7, 8 ; Guest PC9 ; Bagherniya M4, 5, 6 ; Sahebkar A10, 11, 12, 13
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Nutrition Research Center, Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran
  8. 8. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil
  10. 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
  13. 13. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Advances in Experimental Medicine and Biology Published:2021


Abstract

COVID-19 is now pandemic throughout the world, and scientists are searching for effective therapies to prevent or treat the disease. The combination of curcumin and piperine is a potential option for the management of COVID-19 based on several mechanisms including antiviral, anti-inflammatory, immunomodulatory, antifibrotic, and antioxidant effects. Here, we describe the probable mechanism of curcumin-piperine against COVID-19. Administration of curcumin-piperine combination appears as a potential strategy to counterbalance the pathophysiological features of COVID-19 including inflammation. The optimal dose and duration of curcumin-piperine supplementation should be determined in the future. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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