Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Flaxseed Oil Supplementation on Severity of Depression and Brain-Derived Neurotrophic Factor: A Randomized, Double Blind Placebo Controlled Clinical Trial Publisher



Poorbaferani F1 ; Rouhani MH1 ; Heidari Z2, 3 ; Poorbaferani M4, 5 ; Safavi SM1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Cardiac Rehabilitation Research Centre, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Development Care Health for Institute Research Hakim Poursina, Center Research Diseases Hepatobiliary and Gastrointestinal, Isfahan, Iran
  5. 5. Committee Research’ Students Medical, Sciences Medical of University Isfahan, Isfahan, Iran

Source: International Journal of Food Properties Published:2020


Abstract

Emerging clinical studies suggest that flaxseed oil may be an effective intervention for the management of depression. The current trial was conducted to assess the effect of flaxseed oil supplementation on the Brain-derived neurotrophic factor (BDNF), and the psychological status of women with depression. Subjects of 60 depressed women aged 18–45 were randomly divided into two groups. One group was asked to consume a 1000 mg flaxseed oil capsule, twice a day for 10 weeks, while the other consumed a placebo. Serum (BDNF), Beck Depression Inventory-II (BDI-II) questionnaire, and anthropometric indices were measured before and after intervention. This study showed that serum BDNF concentration in the supplementation group increased significantly after 10-week intervention, compared with placebo (1.12 ± 0.6 pg/ml vs. 0.2 ± 0.56 pg/ml; p < .0001). Total BDI-II score was significantly lower after flaxseed oil supplementation, compared with placebo (−16.62 ± 7.03, −8.45 ± 7.8; p < .0001). The present study showed that flaxseed oil supplementation can confer a number of health benefits in depressed women, including increased serum BDNF concentrations, along with improvements in depression status. © 2020, Published with license by Taylor & Francis Group, LLC. © 2020 Fariborz Poorbaferani, Mohamamd Hoseein Rouhani, Zahra Heidari, Maryam Poorbaferani and Sayyed Morteza Safavi.
Related Docs
View other Related Docs
1. Effects of Melatonin Supplementation on Bdnf Concentrations and Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Behavioural Brain Research (2023)
2. Nigella Sativa Extract in the Treatment of Depression and Serum Brain-Derived Neurotrophic Factor (Bdnf) Levels, Journal of Research in Medical Sciences (2022)
3. The Effects of Wheat Germ Consumption on Mental Health and Brain-Derived Neurotrophic Factor in Subjects With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutritional Neuroscience (2022)
4. The Effect of Pro-/Synbiotic Supplementation on the Brain-Derived Neurotrophic Factor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Food and Function (2022)
5. Total Fat and Omega-3 Fatty Acids Intake in Relation to Serum Brain-Derived Neurotrophic Factor (Bdnf) Levels and Psychological Disorders in Iranian Adults, Scientific Reports (2023)
6. Flaxseed Prevents Interferon-Alpha Induced Depressive Behavior in Mice: The Α-Linolenic Acid Is Essential, Research Journal of Pharmacognosy (2021)
7. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women With Anxiety: A Randomized Clinical Trial, International Journal of Preventive Medicine (2019)
8. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
Experts (# of related papers)
View all Related Experts
Azadeh Mesripour (7)
Peyman Adibi (7)
Other Related Docs
9. Lavender and Dodder Combined Herbal Syrup Versus Citalopram in Major Depressive Disorder With Anxious Distress: A Double-Blind Randomized Trial, Journal of Integrative Medicine (2020)
10. Empirically Derived Food-Based Dietary Inflammatory Index Is Associated With Increased Risk of Psychological Disorders in Women, Nutritional Neuroscience (2021)
11. The Association of Ultra-Processed Food Consumption With Adult Mental Health Disorders: A Systematic Review and Dose-Response Meta-Analysis of 260,385 Participants, Nutritional Neuroscience (2023)
12. Gabapentin Prevented Depressive Behavior Initiated by Dexamethasone, Stress or Inflammation in Mice, Bulletin of Pharmaceutical Sciences. Assiut (2024)
13. Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial, Journal of Evidence-Based Complementary and Alternative Medicine (2017)
14. The Gut–Brain Axis and the Impact of Probiotics on Symptoms of Depression: A Review of the Evidence, Gastrointestinal Nursing (2022)
15. Glycemic Index, Glycemic Load, and Depression: A Systematic Review and Meta-Analysis, European Journal of Clinical Nutrition (2019)
16. Effects of Fish-Oil Consumption on Psychological Function Outcomes in Psychosis: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials, Advances in Nutrition (2022)
17. The Effect of Astaxanthin Supplementation on Cognitive Function and Depression in Patients With Type 2 Diabetes: A Double-Blind, Randomised Controlled Trial, Journal of Health System Research (2020)
18. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
19. Comparing the Effectiveness of Vitamin D Plus Iron Vs Vitamin D on Depression Scores in Anemic Females: Randomized Triple-Masked Trial, Medical Journal of the Islamic Republic of Iran (2019)
20. A Synbiotic Mixture Ameliorates Depressive Behavior Induced by Dexamethasone or Water Avoidance Stress in a Mouse Model; [Fare Modelinde Deksametazon Ile Induklenen Depresif Davranisi Veya Sudan Kacinma Stresini Iyilestiren Sinbiyotik Bir Karisim], Turkish Journal of Pharmaceutical Sciences (2021)
21. The Efficacy of Vitamin B6 and Alpha-Lipoic Acid in Preventing Levetiracetam Depressant-Like Behavior in Mice, Thai Journal of Pharmaceutical Sciences (2022)
22. Investigating the Effect of Zinc Supplementation on Probability of Relapse and Mental Health in Patients With Opioid Use Disorder Undergoing Methadone Maintenance Treatment, Substance Abuse: Treatment, Prevention, and Policy (2023)
23. Magnesium Supplementation Beneficially Affects Depression in Adults With Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Frontiers in Psychiatry (2023)
24. The Effect of Zinc Supplementation on Brain Derived Neurotrophic Factor: A Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2021)
25. Influence of Adjuvant Omega-3-Polyunsaturated Fatty Acids on Depression, Sleep, and Emotion Regulation Among Outpatients With Major Depressive Disorders - Results From a Double-Blind, Randomized and Placebo-Controlled Clinical Trial, Journal of Psychiatric Research (2018)
26. Association of Dietary Phytochemical Index and Mental Health in Women: A Cross-Sectional Study, British Journal of Nutrition (2019)
27. Dietary Total Antioxidant Capacity in Relation to Depression and Anxiety in Iranian Adults, Nutrition (2019)
28. Association Between the Dietary Inflammatory Index and Common Mental Health Disorders Profile Scores, Clinical Nutrition (2019)
29. Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients With Major Depressive Disorder: A Randomized, Controlled Clinical Trial, Journal of Nutrition (2016)
30. Efficacy of Herbal Combination of Sedge, Saffron, and Astragalus Honey on Major Neurocognitive Disorder, Journal of Research in Medical Sciences (2018)
31. Association of Mood Disorders With Serum Zinc Concentrations in Adolescent Female Students, Biological Trace Element Research (2017)
32. Evidence for Rosa Damascena Efficacy in Mental Disorders in Preclinical Animal Studies and Clinical Trials: A Systematic Review, Phytotherapy Research (2022)
33. Effect of Flaxseed Powder on Cardiovascular Risk Factor in Dyslipidemic and Hypertensive Patients, International Journal of Preventive Medicine (2019)
34. Empirically Derived Dietary Patterns in Relation to Psychological Disorders, Public Health Nutrition (2016)
35. Higher Vitamin B6intake Is Associated With Lower Depression and Anxiety Risk in Women But Not in Men: A Large Cross-Sectional Study, International Journal for Vitamin and Nutrition Research (2020)
36. Effect of Venlafaxine on Experimental Colitis in Normal and Reserpinised Depressed Rats, Research in Pharmaceutical Sciences (2015)
37. The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta-Analysis of Randomized Clinical Trials, Brain and Behavior (2025)
38. Effects of the Royal Jelly Consumption on Post-Stroke Complications in Patients With Ischemic Stroke: Results of a Randomized Controlled Trial, Frontiers in Nutrition (2023)
39. Saffron Improves Life and Sleep Quality, Glycaemic Status, Lipid Profile and Liver Function in Diabetic Patients: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial, International Journal of Clinical Practice (2021)
40. The Effects of Sesame Oil on Metabolic Biomarkers: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2022)
41. Effect of Probiotics Supplementation on Disease Progression, Depression, General Health, and Anthropometric Measurements in Relapsing-Remitting Multiple Sclerosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials, International Journal of Clinical Practice (2021)
42. Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women With Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Biological Trace Element Research (2020)
43. Impact of Flaxseed Supplementation on Plasma Lipoprotein(A) Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2020)
44. Monosodium Glutamate Influences Depressive Behavior of Two Age Groups of Mice in Forced Swimming Test: Vitamin B6 Could Remedy the Situation, Personalized Medicine in Psychiatry (2019)
45. Effect of Forced Treadmill Exercise on Stimulation of Bdnf Expression, Depression Symptoms, Tactile Memory and Working Memory in Lps-Treated Rats, Behavioural Brain Research (2022)
46. The Antidepressant Effects of Lavender (Lavandula Angustifolia Mill.): A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Complementary Therapies in Medicine (2021)
47. Associations Between Dietary Intake of B-Vitamins and Psychological Disorders Among Iranian Women: A Cross-Sectional Study, Public Health Nutrition (2021)
48. Research Paper: Effect of Aromatherapy With Lavender 10% Essential Oil on Motor Function, Speech and Delirium in Patients With Acute Thrombotic Cerebral Ischemia, Caspian Journal of Neurological Sciences (2019)
49. The Effects of Sesame Oil Consumption on Fatigue and Mental Health Status in Women With Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Controlled Trial, Nutrition and Food Science (2023)
50. Effect of Low-Carbohydrate Diet on Depression and Anxiety: A Systematic Review and Meta-Analysis of Controlled Trials, Journal of Affective Disorders (2023)