Calcium Plus Vitamin D Supplementation Affects Glucose Metabolism and Lipid Concentrations in Overweight and Obese Vitamin D Deficient Women With Polycystic Ovary Syndrome Publisher Pubmed



Asemi Z¹ ; Foroozanfard F² ; Hashemi T² ; Bahmani F¹ ; Jamilian M³ ; Esmaillzadeh A^{4, 5}
Source: Clinical Nutrition Published:2015

Abstract

Background & aims: Few studies have examined the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome (PCOS). This study was conducted to determine the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations among overweight and obese vitamin D deficient women with PCOS. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obese vitamin D deficient women diagnosed with PCOS. Participants were randomly assigned into four groups to receive: 1) 1000mg/d calcium+vitamin D placebo (. n=26); 2) 50,000IU/wk vitamin D+calcium placebo (. n=26); 3) 1000mg calcium/d+50,000IU/wk vitamin D (. n=26) and 4) calcium placebo+vitamin D placebo (. n=26) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to measure glucose metabolism and lipid concentrations. Results: Calcium-vitamin D co-supplementation resulted in higher levels of serum calcium (. P=0.002) and vitamin D (. P<0.001) compared with other groups. Co-supplementation, compared with other groups, led to decreased serum insulin levels (. P=0.03), homeostasis model of assessment-insulin resistance (HOMA-IR) score (. P=0.04) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (. P=0.001). Furthermore, a significant decrease in serum triglycerides (. P=0.02) and VLDL-cholesterol levels (. P=0.02) was seen following the administration of calcium plus vitamin D supplements compared with the other groups. Co-supplementation with calcium and vitamin D had no significant effects on FPG, total-, LDL-, HDL-, and non-HDL-cholesterol levels. Conclusions: In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles.Clinical registration number. www.irct.ir: IRCT201309275623N10. © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.