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The Effect of Sargassum Glaucescens From the Persian Gulf on Neuropathy Pain Induced by Paclitaxel in Mice Publisher



Yegdaneh A1 ; Saeedi A2 ; Shahmiveh T2 ; Vaseghi G3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Advanced Biomedical Research Published:2020


Abstract

Background: Marine seaweeds are a famous type of traditional food containing various kinds of secondary metabolites. These organisms have different biological activities such as antitumor, antiviral, and antioxidant. The aim of this study was to investigate the effects of total extract of Sargassum glaucescens on neuropathy pain induced by paclitaxel in mice. Materials and Methods: S. glaucescens was collected from the Persian Gulf. The seaweed was extracted by maceration with methanol‑ethyl acetate (1:1) solvent. The effect of the extract on neuropathy pain induced by paclitaxel was analyzed. All results were analyzed by one‑way analysis of variance. Results: Acute administration of S. glaucescens extract (100 and 200 mg/kg intraperitoneally [i.p.]) 30 min before the test on the 11th day significantly reduced the duration of paw licking (P < 0.001). Conclusions: Chronic treatment with S. glaucescens extract (100, 150, and 200 mg/kg i.p.) from the 6th day until the 10th day reduced the duration of paw licking. Therefore, S. glaucescens should be considered for further treatment of neuropathy. © 2020 Advanced Biomedical Research | Published by Wolters Kluwer - Medknow.
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