Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nano-Composite of Silk Fibroin-Chitosan/Nano Zro2 for Tissue Engineering Applications: Fabrication and Morphology Publisher Pubmed



Teimouri A1 ; Ebrahimi R1 ; Emadi R2 ; Beni BH3 ; Chermahini AN4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Chemistry Department, Payame Noor University, Tehran, 19395-3697, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  3. 3. Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran

Source: International Journal of Biological Macromolecules Published:2015


Abstract

A scaffold possessing certain desired features such as biodegradation, biocompatibility, and porous structure could serve as a template for tissue engineering. In the present study, silk fibroin (SF), chitosan (CS) and zirconia (Nano ZrO2) were all combined using the freeze drying technique to fabricate a bio-composite scaffold. The composite scaffold (SF/CS/Nano ZrO2) was characterized by SEM, XRD, TGA, BET and FT-IR studies. The scaffold was found to possess a porous nature with pore dimensions suitable for cell infiltration and colonization. The presence of zirconia in the SF/CS/Nano ZrO2 scaffold led to an increase in compressive strength and water uptake capacity while at the same time decreasing the porosity. Cytocompatibility of the SF/CS/Nano ZrO2 scaffold, assessed by MTT assay, revealed non-toxicity to the Human Gingival Fibroblast (HGF, NCBI: C-131). Thus, we suggest that SF/CS/Nano ZrO2 composite scaffold is a potential candidate to be used for tissue engineering. © 2015 Elsevier B.V.
Related Docs
View other Related Docs
1. Fabrication and Characterization of Pom/Zro2/Silk Fibroin Composite Scaffolds, Materials Letters (2015)
2. Fabrication and Characterization of Novel Diopside/Silk Fibroin Nanocomposite Scaffolds for Potential Application in Maxillofacial Bone Regeneration, International Journal of Biological Macromolecules (2013)
3. Incorporation of Chitosan Nanoparticles Into Silk Fibroin-Based Porous Scaffolds: Chondrogenic Differentiation of Stem Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2016)
4. Fabrication of Chitosan/Agarose Scaffolds Containing Extracellular Matrix for Tissue Engineering Applications, International Journal of Biological Macromolecules (2020)
5. Development of Porous Photopolymer Resin-Swcnt Produced by Digital Light Processing Technology Using for Bone Femur Application, Archives of Bone and Joint Surgery (2021)
6. Fabrication of 3D Porous Polyurethane-Graphene Oxide Scaffolds by a Sequential Two-Step Processing for Non-Load Bearing Bone Defects, Physica Scripta (2024)
7. Preparation and Characterization of Silk-Chitosan Composite As a Three- Dimensional Tool for Culturing Osteoblast-Like Cells, Journal of Isfahan Medical School (2015)
8. Silk Fibroin-Chondroitin Sulfate-Alginate Porous Scaffolds: Structural Properties and in Vitro Studies, Journal of Applied Polymer Science (2014)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (82)
Mohammad Rafienia (46)
Other Related Docs
9. Porous Starch/Cellulose Nanofibers Composite Prepared by Salt Leaching Technique for Tissue Engineering, Carbohydrate Polymers (2014)
10. Fabrication and Characterization of Silk/Forsterite Composites for Tissue Engineering Applications, Ceramics International (2014)
11. Nanobiomaterials in Periodontal Tissue Engineering, Nanobiomaterials in Hard Tissue Engineering: Applications of Nanobiomaterials (2016)
12. Evaluation of Mechanical Properties and Cell Viability of Poly (3-Hydroxybutyrate)-Chitosan/Al2o3nanocomposite Scaffold for Cartilage Tissue Engineering, Journal of Medical Signals and Sensors (2019)
13. A New Approach to Fabrication of Cs/Bg/Cnt Nanocomposite Scaffold Towards Bone Tissue Engineering and Evaluation of Its Properties, Applied Surface Science (2015)
14. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
15. Characterization of Silk/Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube Micro-Nano Scaffold: A New Hybrid Scaffold for Tissue Engineering Applications, Journal of Medical Signals and Sensors (2018)
16. Tunable Cellular Interactions and Physical Properties of Nanofibrous Pcl-Forsterite: Gelatin Scaffold Through Sequential Electrospinning, Composites Science and Technology (2013)
17. Fabrication and Characterization of 3D-Printed Composite Scaffolds of Coral-Derived Hydroxyapatite Nanoparticles/Polycaprolactone/Gelatin Carrying Doxorubicin for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
18. Potential of an Electrospun Composite Scaffold of Poly (3-Hydroxybutyrate)-Chitosan/Alumina Nanowires in Bone Tissue Engineering Applications, Materials Science and Engineering C (2019)
19. Poly Glycerol Sebacate/ Polycaprolactone/ Carbon Quantum Dots Fibrous Scaffold As a Multifunctional Platform for Cardiac Tissue Engineering, Materials Chemistry and Physics (2021)
20. Evaluation Avocado Soybean Unsaponifiables Loaded in Poly (Lactic-Co-Glycolic) Acid/Avocado Soybean Unsaponifiables-Fibrin Nanoparticles Scaffold (New Delivery System) Is an Effective Factor for Tissue Engineering, Advanced Biomedical Research (2021)
21. Evaluation of the Effects of Multiwalled Carbon Nanotubes on Electrospun Poly(3-Hydroxybutirate) Scaffold for Tissue Engineering Applications, Journal of Porous Materials (2018)
22. Poly (Glycerol Sebacate) and Polyhydroxybutyrate Electrospun Nanocomposite Facilitates Osteogenic Differentiation of Mesenchymal Stem Cells, Journal of Drug Delivery Science and Technology (2021)
23. Pmma Nanofibers Containing Keplerate-Type Polyoxometalate and Metronidazole: Preparation and Wound-Healing Effect in a Rat Model, Journal of Drug Delivery Science and Technology (2022)
24. Physical, Mechanical and Biological Performance of Phb-Chitosan/Mwcnts Nanocomposite Coating Deposited on Bioglass Based Scaffold: Potential Application in Bone Tissue Engineering, International Journal of Biological Macromolecules (2020)
25. Modification of Porous Calcium Phosphate Surfaces With Different Geometries of Bioactive Glass Nanoparticles, Materials Science and Engineering C (2012)
26. A 3D Nanostructured Calcium-Aluminum-Silicate Scaffold With Hierarchical Meso-Macroporosity for Bone Tissue Regeneration: Fabrication, Sintering Behavior, Surface Modification and in Vitro Studies, Journal of the European Ceramic Society (2021)
27. Differential Effects of Rat Adscs Encapsulation in Fibrin Matrix and Combination Delivery of Bdnf and Gold Nanoparticles on Peripheral Nerve Regeneration, BMC Neuroscience (2021)
28. Nanofibrous Chitosan-Polyethylene Oxide Engineered Scaffolds: A Comparative Study Between Simulated Structural Characteristics and Cells Viability, BioMed Research International (2014)
29. A Modular Approach to 3D-Printed Bilayer Composite Scaffolds for Osteochondral Tissue Engineering, Journal of Materials Science: Materials in Medicine (2024)
30. Preparation of Nanostructure Bioactive Diopside Scaffolds for Bone Tissue Engineering by Two Near Net Shape Manufacturing Techniques, Materials Letters (2016)
31. Baghdadite/Polycaprolactone Nanocomposite Scaffolds: Preparation, Characterisation, and in Vitro Biological Responses of Human Osteoblast-Like Cells (Saos-2 Cell Line), Materials Technology (2020)
32. Effects of Multi-Wall Carbon Nanotubes on Structural and Mechanical Properties of Poly(3-Hydroxybutyrate)/Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering, Bulletin of Materials Science (2017)
33. Highly Porous 3D Printed Scaffold Incorporated With Graphene Oxide-Merwinite and Coated With Igf1 Loaded Nanofibers for Calvarial Defect Repair, Journal of Polymers and the Environment (2024)
34. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
35. Sodium Alginate/Magnesium Oxide Nanocomposite Scaffolds for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
36. Incorporating Fingolimod Through Poly(Lactic-Co-Glycolic Acid) Nanoparticles in Electrospun Polyurethane/Polycaprolactone/Gelatin Scaffold: An in Vitro Study for Nerve Tissue Engineering, Polymers for Advanced Technologies (2022)
37. Plasma Surface Modification of Electrospun Polyhydroxybutyrate (Phb) Nanofibers to Investigate Their Performance in Bone Tissue Engineering, International Journal of Biological Macromolecules (2023)
38. Incorporation of Nanohydroxyapatite and Vitamin D3 Into Electrospun Pcl/Gelatin Scaffolds: The Influence on the Physical and Chemical Properties and Cell Behavior for Bone Tissue Engineering, Polymers for Advanced Technologies (2018)
39. Nano/Micro Hybrid Scaffold of Pcl or P3hb Nanofibers Combined With Silk Fibroin for Tendon and Ligament Tissue Engineering, Journal of Applied Biomaterials and Functional Materials (2015)
40. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
41. A Novel Flexible, Conductive, and Three-Dimensional Reduced Graphene Oxide/Polyurethane Scaffold for Cell Attachment and Bone Regeneration, Materials and Design (2022)
42. Preparation and Characterization of Poly Ε-Caprolactone-Gelatin/Multi-Walled Carbon Nanotubes Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Polymeric Materials and Polymeric Biomaterials (2020)
43. Preparation of Fibrin/Poly Vinyl Alcohol Electrospun Nanofibers Scaffold for Tissue Engineering Applications, Journal of Isfahan Medical School (2016)
44. 3D Printed Polylactic Acid-Based Nanocomposite Scaffold Stuffed With Microporous Simvastatin-Loaded Polyelectrolyte for Craniofacial Reconstruction, International Journal of Biological Macromolecules (2024)
45. A Comparison Between Cell Viability of Chondrocytes on a Biodegradable Polyester Urethane Scaffold and Alginate Beads in Different Oxygen Tension and Ph, Iranian Polymer Journal (English Edition) (2005)
46. Zeolitic Imidazolate Frameworks: From Bactericidal Properties to Tissue Regeneration, Journal of Controlled Release (2023)
47. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)
48. Synthetic Electrospun Nanofibers As a Supportive Matrix in Osteogenic Differentiation of Induced Pluripotent Stem Cells, Journal of Biomaterials Science, Polymer Edition (2022)
49. Polycaprolactone/Gelatin/Hydroxyapatite Nanocomposite Scaffold Seeded With Stem Cells From Human Exfoliated Deciduous Teeth to Enhance Bone Repair: In Vitro and in Vivo Studies, Materials Technology (2022)
50. Preparation of a Novel Biodegradable Nanocomposite Scaffold Based on Poly (3-Hydroxybutyrate)/Bioglass Nanoparticles for Bone Tissue Engineering, Journal of Materials Science: Materials in Medicine (2010)