Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue

Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue Publisher

Asadi M¹ ; Ghahari M^{1, 2} ; Hassanzadehtabrizi SA¹ ; Arabi AM² ; Nasiri R³

Show Affiliations

1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2. Department of Nano Materials and Nano Coatings, Institute for Color Science and Technology (ICST), Tehran, Iran
3. Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran

Source: Materials Research Express Published:2019

Abstract

In this study, NaLuF4: Yb +, Tm +3 3 upconversion nanoparticles were synthesized in less than 6 h under thermal decomposition conditions by changing pHand synthesis temperature. The washing process removed the hydrophobic species on the surface of nanoparticles. Then the nanoparticles were coated by calcium carbonate (CaCO3) and were loaded with curcumin (Cur) as a drug model in one synthesis step. The effects of toxicity of uncoated and coated nanoparticles were investigated on normal cells, blood factors, and histopathology of the tissue in Balb/Cmice. The most of synthesized nanoparticles had spherical shape considering the results from the SEM and TEM. The results of the DLS analysis showed that the hydrodynamic diameter of the uncoated and coated nanoparticles was 49.52 and 59.37 nm, respectively. By injecting CaCO3@NPs nanoparticles into human blood, there was not seen a significant difference in the number of red blood cells, white blood cells, hemoglobin, and blood platelets with the treatment of the control group. Besides, cell biocompatibility studies in fibroblast cell lines showed that the toxicity of uncoated nanoparticles increased at concentrations higher than 250 mg/ml.Also, cytotoxicity increases significantlywith increasing the time of 24, 48, and 72 h. The coated samples did not represent the toxicity effect. The results of cellular changes induced by the addition of uncoated and coated nanoparticles showed that the cells change from spherical to Spindle after treatmentwith CaCO3@NPs,Which indicates a lack of toxicity. Histopathological examination of vital organs inmice receiving CaCO3@NPs did not showany pathological damage compared to the control group. © 2020 IOP Publishing Ltd.

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Style	Citing Format
MLA	Asadi M, et al.. "Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue." Materials Research Express, vol. 6, no. 12, 2019, pp. -.
APA	Asadi M, Ghahari M, Hassanzadehtabrizi SA, Arabi AM, Nasiri R (2019). Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue. Materials Research Express, 6(12), -.
Chicago	Asadi M, Ghahari M, Hassanzadehtabrizi SA, Arabi AM, Nasiri R. "Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue." Materials Research Express 6, no. 12 (2019): -.
Harvard	Asadi M et al. (2019) 'Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue', Materials Research Express, 6(12), pp. -.
Vancouver	Asadi M, Ghahari M, Hassanzadehtabrizi SA, Arabi AM, Nasiri R. Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue. Materials Research Express. 2019;6(12):-.
BibTex	@article{ author = {Asadi M and Ghahari M and Hassanzadehtabrizi SA and Arabi AM and Nasiri R}, title = {Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue}, journal = {Materials Research Express}, volume = {6}, number = {12}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Asadi M AU - Ghahari M AU - Hassanzadehtabrizi SA AU - Arabi AM AU - Nasiri R TI - Studying the Toxicity Effects of Coated and Uncoated Naluf4: Yb3+, Tm3+ Upconversion Nanoparticles on Blood Factors and Histopathology for Balb/C Mice's Tissue JO - Materials Research Express VL - 6 IS - 12 SP - EP - PY - 2019 ER -

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