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Green Synthesis of Bimetallic Zno–Cuo Nanoparticles and Their Cytotoxicity Properties Publisher Pubmed



Cao Y1 ; Dhahad HA2 ; Elshorbagy MA3, 4 ; Alijani HQ5 ; Zakeri M6 ; Heydari A7 ; Bahonar E8 ; Slouf M9 ; Khatami M10 ; Naderifar M11 ; Iravani S12 ; Khatami S13 ; Dehkordi FF14
Authors

Source: Scientific Reports Published:2021


Abstract

In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low. © 2021, The Author(s).
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