Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Gold-Coated Iron Oxide Nanoparticles As a Potential Photothermal Therapy Agent to Enhance Eradication of Breast Cancer Cells Publisher



Dheyab MA1, 2 ; Aziz AA1, 2 ; Jameel MS1, 2 ; Khaniabadi PM1, 2 ; Mehrdel B1, 2 ; Khaniabadi BM3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Pulau Pinang, 11800, Malaysia
  2. 2. Nano-Optoelectronic Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, Pulau Pinang, 11800, Malaysia
  3. 3. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Physics: Conference Series Published:2020


Abstract

Iron oxide nanoparticles (Fe3O4 NPs) possess unique physicochemical properties which make them great for biomedical applications. This study reports the development of gold (Au) coated Fe3O4 (Au-Fe3O4 NPs) for photothermal therapy to eradicate breast cancer cells (MCF-7). The spherical shape of monodisperse Au-Fe3O4 NPs with an average size of 20.8 nm was confirmed by TEM. The cell viability evaluation of Au-Fe3O4 NPs showed negligible toxicity toward MCF-7 cells after 24 h. Significant cell reduction was observed for MCF-7 (73.9%) cells following photothermal therapy at highest concentration of NPs (50 μgFe/ml) for 10 minutes illumination when compared with other intervention groups. It can be concluded that, the synthesized Au-Fe3O4 NPs is an effective and promising photothermal therapy agent for breast cancer treatment. © 2020 IOP Publishing Ltd. All rights reserved.
Related Docs
View other Related Docs
1. Optimal Scheduling of the Nanoparticle-Mediated Cancer Photo-Thermo-Radiotherapy, Photodiagnosis and Photodynamic Therapy (2020)
2. Iron Oxide Nanoparticles Coated With Polydopamine As a Potential Nano-Photothermal Agent for Treatment of Melanoma Cancer: An in Vivo Study, Lasers in Medical Science (2022)
3. Assessment of Ploy Dopamine Coated Fe3o4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection, Anti-Cancer Agents in Medicinal Chemistry (2020)
4. Targeted Photothermal Therapy of Melanoma in C57bl/6 Mice Using Fe3 O4 @Au Core-Shell Nanoparticles and Near-Infrared Laser, Journal of Biomedical Physics and Engineering (2021)
5. Breast Cancer Cell Targeted Mr Molecular Imaging Probe: Anti-Muc1 Antibody-Based Magnetic Nanoparticles, Journal of Physics: Conference Series (2017)
6. Synthesis and Application of Fe3o4@Au Composite Nanoparticles As Magnetic Resonance/Computed Tomography Dual-Modality Contrast Agent, Journal of Medical Signals and Sensors (2020)
7. Trastuzumab Conjugated Porphyrin-Superparamagnetic Iron Oxide Nanoparticle: A Potential Ptt-Mri Bimodal Agent for Herceptin Positive Breast Cancer, Photodiagnosis and Photodynamic Therapy (2020)
8. Investigation of Combination Effect Between 6 Mv X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-Mg Cancer Cells, Journal of Biomedical Physics and Engineering (2020)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (26)
Seyed Hossein Hejazi (6)
Other Related Docs
9. Nanophotocatalysts in Biomedicine: Cancer Therapeutic, Tissue Engineering, Biosensing, and Drug Delivery Applications, Environmental Research (2023)
10. Assessment of Superparamagnetic Iron Oxide Nanoparticles Conjugated With Anti-Epidermal Growth Factor Receptor Antibody for the Detection of Lung Cancer by Magnetic Resonance Imaging (Mri) in C57bl/6, Journal of Isfahan Medical School (2021)
11. Iron Oxide/Gold Nanoparticles-Decorated Reduced Graphene Oxide Nanohybrid As the Thermo-Radiotherapy Agent, IET Nanobiotechnology (2020)
12. Removal of Rr198 Dye by Tio2/Fe3o4/Persulfate Nanoparticles Under Uv-Led Irradiation and Comparision of Ofat and Ccd Experimental Design in Rsm Modelling, Indian Journal of Chemical Technology (2020)
13. Porphyrin–Iron Oxide Nanoparticle Functionalized With Trastuzumab (Ion–Pp–Tz) Potential Mr Imaging Probe for Breast Cancer Cells, Applied Physics A: Materials Science and Processing (2022)
14. Au Nanoparticles in the Diagnosis and Treatment of Ovarian Cancer: A New Horizon in the Personalized Medicine, Nanomedicine Research Journal (2022)
15. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
16. Investigating the Effectiveness of 6 Mev Electron and Ultrasound Beams With the Use of Iron Oxide Magnetic Nanoparticles Attached to Cisplatin on B16f10 Cells: In-Vitro Study, International Journal of Nanoscience (2024)
17. Iron Oxyhydroxide Nanoparticles: Green Synthesis and Their Cytotoxicity Activity Against A549 Human Lung Adenocarcinoma Cells, Rendiconti Lincei (2022)
18. Challenges and Opportunities of Using Fluorescent Metal Nanocluster-Based Colorimetric Assays in Medicine, ACS Omega (2023)
19. Chitosan–Imidazolium Core–Shell Nanoparticles of Gd-Mn-Mo Polyoxometalate As Novel Potential Mri Nano-Agent for Breast Cancer Detection, Micromachines (2023)
20. Mxenes in Photomedicine: Advances and Prospects, Chemical Communications (2022)
21. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
22. Activation of Persulfate by Tio2-Fe3 O4 Nanocomposite for Reactive Red 198 Degradation Along With Modeling and Optimization Approach, Environmental Health Engineering and Management (2023)
23. Mxenes for Cancer Therapy and Diagnosis: Recent Advances and Current Challenges, ACS Biomaterials Science and Engineering (2021)
24. The Role of Folic Acid-Conjugated Polyglycerol Coated Iron Oxide Nanoparticles on Radiosensitivity With Clinical Electron Beam (6 Mev) on Human Cervical Carcinoma Cell Line: In Vitro Study, Journal of Photochemistry and Photobiology B: Biology (2018)
25. Magnetic Polyvinyl Caprolactam–Polyvinyl Acetate–Polyethylene Glycol Micelles for Docetaxel Delivery in Breast Cancer: An in Vitro Study on Two Cell Lines of Breast Cancer, Pharmaceutical Development and Technology (2017)
26. Could Fa-Pg-Spions Act As a Hyperthermia Sensitizing Agent? an in Vitro Study, Journal of Thermal Biology (2018)
27. The Therapeutic Effect of Combination of X-Ray and Iron Oxide Nanoparticles Attached to Dacarbazine Chemotherapy Drug on Melanoma Cell Line, Journal of Isfahan Medical School (2022)
28. Optical, Physical and Quantum Properties of Gold Nanoparticles and Its Applications in Diagnosis and Treatment of Cancers, Journal of Isfahan Medical School (2015)
29. Biosynthesis of Core–Shell Α-Fe2o3@Au Nanotruffles and Their Biomedical Applications, Biomass Conversion and Biorefinery (2024)
30. Synthesis and Characterisation of Iron Oxide Nanoparticles Conjugated With Epidermal Growth Factor Receptor (Egfr) Monoclonal Antibody As Mri Contrast Agent for Cancer Detection, IET Nanobiotechnology (2019)
31. Recent Advances in Nanomaterials Development for Nanomedicine and Cancer, ACS Applied Bio Materials (2021)
32. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
33. Advanced Mxene-Based Micro- and Nanosystems for Targeted Drug Delivery in Cancer Therapy, Micromachines (2022)
34. Functionalized Magnetic Nanoparticles for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices (2024)
35. Polyoxometalates As Next-Generation of Theragnostic Gadgets in Cancer, Reviews in Inorganic Chemistry (2024)
36. Cobalt Zinc Ferrite Nanoparticles As a Potential Magnetic Resonance Imaging Agent: An in Vitro Study, Avicenna Journal of Medical Biotechnology (2015)
37. Magnetic Iron Oxide Nanoparticles As T2 Mr Imaging Contrast Agent for Detection of Breast Cancer (Mcf-7) Cell, Avicenna Journal of Medical Biotechnology (2017)
38. Biosynthesis of Zn-Doped Cufe2o4 Nanoparticles and Their Cytotoxic Activity, Scientific Reports (2022)
39. Solvothermal Synthesis of Magnetic Spinel Ferrites, Journal of Medical Signals and Sensors (2018)
40. Biodistribution and Toxicity Assessment of Radiolabeled and Dmsa Coated Ferrite Nanoparticles in Mice, Journal of Radioanalytical and Nuclear Chemistry (2012)
41. In Vivo Study of Anti-Epidermal Growth Factor Receptor Antibody-Based Iron Oxide Nanoparticles (Anti-Egfr-Spions) As a Novel Mr Imaging Contrast Agent for Lung Cancer (Llc1) Cells Detection, IET Nanobiotechnology (2020)
42. Aptamer-Conjugated Magnetic Nanoparticles As Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer, Journal of Medical Signals and Sensors (2016)
43. Synthesis and Cytotoxicity Assessment of Gold-Coated Magnetic Iron Oxide Nanoparticles, Journal of Biomedical Physics and Engineering (2018)
44. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
45. Magnetic Chondroitin Targeted Nanoparticles for Dual Targeting of Montelukast in Prevention of In-Stent Restenosis, RSC Advances (2016)
46. Synthesis and Characterization of Core-Shell Fe 3O 4-Gold-Chitosan Nanostructure, Journal of Nanobiotechnology (2012)
47. An Investigation on Polycaprolactone/Chitosan/Fe3o4 Nanofibrous Composite Used for Hyperthermia, Polymers for Advanced Technologies (2019)
48. Papain Grafted Into the Silica Coated Iron-Based Magnetic Nanoparticles 'Ionps@Sio2-Ppn' As a New Delivery Vehicle to the Hela Cells, Nanotechnology (2020)
49. Multifunctional Gold Helix Phototheranostic Biohybrid That Enables Targeted Image-Guided Photothermal Therapy in Breast Cancer, ACS Applied Materials and Interfaces (2022)
50. Multifunctional Magnetic Nanostructured Hardystonite Scaffold for Hyperthermia, Drug Delivery and Tissue Engineering Applications, Materials Science and Engineering C (2017)