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Fabrication and Characterization of Electrospun Poly Lactic-Co-Glycolic Acid/Zeolite Nanocomposite Scaffolds Using Bone Tissue Engineering Publisher



Davarpanah Jazi R1 ; Rafienia M2 ; Salehi Rozve H3 ; Karamian E4 ; Sattary M5
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering, Islamic Azad University, Isfahan, Iran
  2. 2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Biomaterials Group, Department of Materials Engineering, Islamic Azad University, Isfahan, Iran
  5. 5. Department of Biomedical Engineering, Islamic Azad University, Tehran, Iran

Source: Journal of Bioactive and Compatible Polymers Published:2018


Abstract

Poly lactic-co-glycolic acid/zeolite nanocomposite scaffolds were prepared with 17 (wt%) poly lactic-co-glycolic acid (75:25) and 3, 7, and 10 (wt%) nanocrystalline zeolite particles by electrospinning poly lactic-co-glycolic acid and nanocrystalline zeolite with an average diameter of crystals equal to 42 nm. The field-emission scanning electron microscope images confirmed that fibers had no beads. In vitro mineralization in the simulated body fluid revealed that the poly lactic-co-glycolic acid/zeolite nanoscaffolds had strong bioactivity behavior and apatite crystals were formed on the scaffolds. Mechanical properties were improved in the nanocomposite scaffolds compared to the poly lactic-co-glycolic acid scaffold. Biodegradation of scaffolds was tested by being immersed and incubated in phosphate-buffered saline for 90 days, and the effect of zeolite on the degradation rate was also studied. The biological performance of nanoscaffolds and poly lactic-co-glycolic acid was assessed by in vitro culture of MG63 osteosarcoma cell line, 3-(4,5-dimethylthiazol-2-yl)-2,5-dimethiyltetrazolium-bromide assay, and 4′,6-diamidino-2-phenylindole staining. All types of scaffolds were cell compatible and could support cell proliferation. Poly lactic-co-glycolic acid/zeolite (3 and 7 (wt%)) showed cell viability and proliferation since 1, 4, and 7 days after the implantation. The cell adherence to the scaffolds was also studied by scanning electron microscope images. The results showed that MG63 cells adhered to the nanocomposites. Besides, all the results illustrated that nanocomposite scaffold with 7 (wt%) zeolite is the most suitable scaffold for bone tissue engineering. © The Author(s) 2017.
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