In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs

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In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs Publisher Pubmed

Badali H¹ ; Mohammadi R² ; Mashedi O³ ; De Hoog GS^{4, 5, 6, 7, 8, 9} ; Meis JF^{10, 11}

Source: Mycoses Published:2015

Abstract

Despite the common, worldwide, occurrence of dermatophytes, little information is available regarding susceptibility profiles against currently available and novel antifungal agents. A collection of sixty-eight clinical Trichophyton species and Epidermophyton floccosum were previously identified and verified to the species level by sequencing the internal transcribed spacer (ITS) regions of rDNA. MICs of amphotericin B, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, terbinafine and MECs of caspofungin and anidulafungin were performed based on CLSI M38-A2. The resulting MIC90s of all strains were, in increasing order, as follows: terbinafine (0.063mgl-1); posaconazole (1mgl-1); isavuconazole and anidulafungin (2mgl-1); itraconazole, voriconazole, amphotericin B, and caspofungin (4mgl-1) and fluconazole (>64mgl-1). These results confirm that terbinafine is an excellent agent for treatment of dermatophytosis due to T. rubrum, T. mentagrophytes, T. verrucosum, T. schoenleinii and E. floccosum. In addition, the new azoles POS and ISA are potentially useful antifungals to treat dermatophytosis. However, the clinical effectiveness of these novel antifungals remains to be determined. © 2015 Blackwell Verlag GmbH.

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Style	Citing Format
MLA	Badali H, et al.. "In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs." Mycoses, vol. 58, no. 5, 2015, pp. 303-307.
APA	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF (2015). In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs. Mycoses, 58(5), 303-307.
Chicago	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF. "In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs." Mycoses 58, no. 5 (2015): 303-307.
Harvard	Badali H et al. (2015) 'In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs', Mycoses, 58(5), pp. 303-307.
Vancouver	Badali H, Mohammadi R, Mashedi O, De Hoog GS, Meis JF. In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs. Mycoses. 2015;58(5):303-307.
BibTex	@article{ author = {Badali H and Mohammadi R and Mashedi O and De Hoog GS and Meis JF}, title = {In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs}, journal = {Mycoses}, volume = {58}, number = {5}, pages = {303-307}, year = {2015} }
RIS	TY - JOUR AU - Badali H AU - Mohammadi R AU - Mashedi O AU - De Hoog GS AU - Meis JF TI - In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs JO - Mycoses VL - 58 IS - 5 SP - 303 EP - 307 PY - 2015 ER -

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