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Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole



Noroozmirzaaghakhani I1, 2 ; Dehghan P1, 2 ; Mohammadi R1, 2 ; Moattar F3 ; Mahaki B4
Authors
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Authors Affiliations
  1. 1. Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmacology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Candidiasis is one of the most important fungal infections caused by different species of Candida. The most common etiologic agent is Candida albicans. In recent years, there are many reports about the failure treatment of patients with different clinical forms of candidiasis. Statins have been found to have antifungal activity as well as cholesterol-lowering effects. Anethum graveolens has also exhibited antifungal and anti-hyperlipidemic activities. The purpose of the present study was evaluation of antifungal activity of Anethum graveolens and atrovastatin against Candida species in comparison with fluconazole. Methods: The present study was performed on 10 previously identified Candida isolates. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) results were obtained and compared using microdilution method for fluconazole, atrovastatin and Anethum graveolens extract. Findings: Of 10 Candida isolates, 5 (50%) were susceptible to fluconazole and 3 (30%) were dosedependent. Two isolates, including Candida albicans and Candida krusei, were resistant to fluconazole. MIC range for atrovastatin was 32-128 μg/ml. Conclusion: In this study, our finding showed that atrovastatin has antifungal activity as the same previous reports; but, aqueous extract of Anethum graveolens showed no antifungal activity against the Candida species (Candida albicans, Candida parapsilosis, Candida krusei, Candida glabrata, and Candida kefyr). © 2015, Isfahan University of Medical Sciences(IUMS). All Rights Reserved.
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