Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3

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Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3 Publisher Pubmed

Kinkar L¹ ; Laurimae T¹ ; Balkaya I² ; Casulli A³ ; Zait H⁴ ; Irshadullah M⁵ ; Sharbatkhori M⁶ ; Mirhendi H⁷ ; Rostaminejad M⁸ ; Poncegordo F⁹ ; Rehbein S¹⁰ ; Kia EB¹¹ ; Simsek S¹² ; Snabel V¹³ Show All Authors

Kinkar L¹
Laurimae T¹
Balkaya I²
Casulli A³
Zait H⁴
Irshadullah M⁵
Sharbatkhori M⁶
Mirhendi H⁷
Rostaminejad M⁸
Poncegordo F⁹
Rehbein S¹⁰
Kia EB¹¹
Simsek S¹²
Snabel V¹³
Umhang G¹⁴
Varcasia A¹⁵
Saarma U¹

Source: Parasitology Published:2018

Abstract

Cystic echinococcosis (CE) is a severe parasitic disease caused by the species complex Echinococcus granulosus sensu lato. Human infections are most commonly associated with E. granulosus sensu stricto (s.s.), comprising genotypes G1 and G3. The objective of the current study was to provide first insight into the genetic diversity and phylogeography of genotype G3. Despite the epidemiological importance of the genotype, it has remained poorly explored due to the ambiguity in the definition of the genotype. However, it was recently demonstrated that long sequences of mitochondrial DNA (mtDNA) provide a reliable method to discriminate G1 and G3 from each other. Therefore, we sequenced near-complete mtDNA of 39 G3 samples, covering most of the known distribution range and host spectra of the genotype. The phylogenetic network revealed high genetic variation within E. granulosus s.s. G3 and while G3 is significantly less prevalent worldwide than G1, the genetic diversity of both of the genotypes is equally high. We also present the results of the Bayesian phylogeographic analysis, which yielded several well-supported diffusion routes of genotype G3 originating from Turkey and Iran, suggesting the Middle East as the origin of the genotype. Copyright © Cambridge University Press 2018.

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Style	Citing Format
MLA	Kinkar L, et al.. "Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3." Parasitology, vol. 145, no. 12, 2018, pp. 1613-1622.
APA	Kinkar L, Laurimae T, Balkaya I, Casulli A, Zait H, Irshadullah M, Sharbatkhori M, Mirhendi H, Rostaminejad M, Poncegordo F, Rehbein S, Kia EB, Simsek S, Snabel V, Umhang G, Varcasia A, Saarma U (2018). Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3. Parasitology, 145(12), 1613-1622.
Chicago	Kinkar L, Laurimae T, Balkaya I, Casulli A, Zait H, Irshadullah M, Sharbatkhori M, et al.. "Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3." Parasitology 145, no. 12 (2018): 1613-1622.
Harvard	Kinkar L et al. (2018) 'Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3', Parasitology, 145(12), pp. 1613-1622.
Vancouver	Kinkar L, Laurimae T, Balkaya I, Casulli A, Zait H, Irshadullah M, et al.. Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3. Parasitology. 2018;145(12):1613-1622.
BibTex	@article{ author = {Kinkar L and Laurimae T and Balkaya I and Casulli A and Zait H and Irshadullah M and Sharbatkhori M and Mirhendi H and Rostaminejad M and Poncegordo F and Rehbein S and Kia EB and Simsek S and Snabel V and Umhang G and Varcasia A and Saarma U}, title = {Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3}, journal = {Parasitology}, volume = {145}, number = {12}, pages = {1613-1622}, year = {2018} }
RIS	TY - JOUR AU - Kinkar L AU - Laurimae T AU - Balkaya I AU - Casulli A AU - Zait H AU - Irshadullah M AU - Sharbatkhori M AU - Mirhendi H AU - Rostaminejad M AU - Poncegordo F AU - Rehbein S AU - Kia EB AU - Simsek S AU - Snabel V AU - Umhang G AU - Varcasia A AU - Saarma U TI - Genetic Diversity and Phylogeography of the Elusive, But Epidemiologically Important Echinococcus Granulosus Sensu Stricto Genotype G3 JO - Parasitology VL - 145 IS - 12 SP - 1613 EP - 1622 PY - 2018 ER -