Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis

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Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis Publisher Pubmed

Khamesipour A¹ ; Dowlati Y¹ ; Asilian A² ; Hashemifesharki R³ ; Javadi A⁴ ; Noazin S⁵ ; Modabber F^{5, 6}

Source: Vaccine Published:2005

Abstract

To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines. © 2005 Elsevier Ltd. All rights reserved.

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Style	Citing Format
MLA	Khamesipour A, et al.. "Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis." Vaccine, vol. 23, no. 28, 2005, pp. 3642-3648.
APA	Khamesipour A, Dowlati Y, Asilian A, Hashemifesharki R, Javadi A, Noazin S, Modabber F (2005). Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis. Vaccine, 23(28), 3642-3648.
Chicago	Khamesipour A, Dowlati Y, Asilian A, Hashemifesharki R, Javadi A, Noazin S, Modabber F. "Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis." Vaccine 23, no. 28 (2005): 3642-3648.
Harvard	Khamesipour A et al. (2005) 'Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis', Vaccine, 23(28), pp. 3642-3648.
Vancouver	Khamesipour A, Dowlati Y, Asilian A, Hashemifesharki R, Javadi A, Noazin S, et al.. Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis. Vaccine. 2005;23(28):3642-3648.
BibTex	@article{ author = {Khamesipour A and Dowlati Y and Asilian A and Hashemifesharki R and Javadi A and Noazin S and Modabber F}, title = {Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis}, journal = {Vaccine}, volume = {23}, number = {28}, pages = {3642-3648}, year = {2005} }
RIS	TY - JOUR AU - Khamesipour A AU - Dowlati Y AU - Asilian A AU - Hashemifesharki R AU - Javadi A AU - Noazin S AU - Modabber F TI - Leishmanization: Use of an Old Method for Evaluation of Candidate Vaccines Against Leishmaniasis JO - Vaccine VL - 23 IS - 28 SP - 3642 EP - 3648 PY - 2005 ER -

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