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Immune and Bioinformatics Identification of T Cell and B Cell Epitopes in the Protein Structure of Sars-Cov-2: A Systematic Review Publisher Pubmed



Noorimotlagh Z1, 2 ; Karami C3 ; Mirzaee SA1, 2 ; Kaffashian M4 ; Mami S5 ; Azizi M6
Authors
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Authors Affiliations
  1. 1. Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran
  2. 2. Department of Environmental Health Engineering, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran
  3. 3. Department of Microbiology, Parasitology and Immunology, Ardebil University of Medical Sciences, Ardebil, Iran
  4. 4. Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  5. 5. Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Immunopharmacology Published:2020


Abstract

The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus. © 2020 Elsevier B.V.
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