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Genetics and Genomics of Sars-Cov-2: A Review of the Literature With the Special Focus on Genetic Diversity and Sars-Cov-2 Genome Detection Publisher Pubmed



Rahimi A1 ; Mirzazadeh A2, 3 ; Tavakolpour S4
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Joint Bioinformatics Graduate Program, University of Arkansas Little Rock and University of Arkansas for Medical Sciences, Little Rock, AR, United States
  4. 4. Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02215, MA, United States

Source: Genomics Published:2021


Abstract

The outbreak of 2019-novel coronavirus disease (COVID-19), caused by SARS-CoV-2, started in late 2019; in a short time, it has spread rapidly all over the world. Although some possible antiviral and anti-inflammatory medications are available, thousands of people are dying daily. Well-understanding of the SARS-CoV-2 genome is not only essential for the development of new treatments/vaccines, but it also can be used for improving the sensitivity and specificity of current approaches for virus detection. Accordingly, we reviewed the most critical findings related to the genetics of the SARS-CoV-2, with a specific focus on genetic diversity and reported mutations, molecular-based diagnosis assays, using interfering RNA technology for the treatment of patients, and genetic-related vaccination strategies. Additionally, considering the unanswered questions or uncertainties in these regards, different topics were discussed. © 2020 Elsevier Inc.
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