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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney Publisher Pubmed



Wain LV1 ; Vaez A3, 8 ; Jansen R9 ; Joehanes R10, 11 ; Van Der Most PJ3 ; Erzurumluoglu AM1 ; Oreilly PF12 ; Cabrera CP14, 15 ; Warren HR14, 15 ; Rose LM16 ; Verwoert GC17 ; Hottenga JJ20 ; Strawbridge RJ21, 22 ; Esko T23, 26, 27 Show All Authors
Authors
  1. Wain LV1
  2. Vaez A3, 8
  3. Jansen R9
  4. Joehanes R10, 11
  5. Van Der Most PJ3
  6. Erzurumluoglu AM1
  7. Oreilly PF12
  8. Cabrera CP14, 15
  9. Warren HR14, 15
  10. Rose LM16
  11. Verwoert GC17
  12. Hottenga JJ20
  13. Strawbridge RJ21, 22
  14. Esko T23, 26, 27
  15. Arking DE28
  16. Hwang SJ29, 33
  17. Guo X34
  18. Kutalik Z36, 37
  19. Trompet S38, 39
  20. Shrine N1
  21. Teumer A43, 46
  22. Ried JS47
  23. Bis JC48
  24. Smith AV52, 53
  25. Amin N18
  26. Nolte IM3
  27. Lyytikainen LP54, 55
  28. Mahajan A56
  29. Wareham NJ58
  30. Hofer E59, 60
  31. Joshi PK62
  32. Kristiansson K69
  33. Traglia M71
  34. Havulinna AS69
  35. Goel A56, 57
  36. Nalls MA30, 72
  37. Sober S24
  38. Vuckovic D73, 74
  39. Luan J58
  40. Del Greco FM75
  41. Ayers KL76
  42. Marrugat J79
  43. Ruggiero D80
  44. Lopez LM63, 81, 82
  45. Niiranen T69
  46. Enroth S84
  47. Jackson AU85
  48. Nelson CP2, 86
  49. Huffman JE87
  50. Zhang W90, 95
  51. Marten J87
  52. Gandin I74
  53. Harris SE63, 88, 89
  54. Zemunik T96
  55. Lu Y77
  56. Evangelou E90, 97
  57. Shah N98, 99
  58. De Borst MH4
  59. Mangino M13, 100
  60. Prins BP101
  61. Campbell A64, 65
  62. Ligao R40
  63. Chauhan G102, 103
  64. Oldmeadow C104
  65. Abecasis G105
  66. Abedi M106
  67. Barbieri CM71
  68. Barnes MR14, 15
  69. Batini C1
  70. Beilby J107, 108, 109
  71. Blake T1
  72. Boehnke M85
  73. Bottinger EP77
  74. Braund PS2, 86
  75. Brown M14, 15
  76. Brumat M74
  77. Campbell H62
  78. Chambers JC90, 95, 112
  79. Cocca M74
  80. Collins F31
  81. Connell J113
  82. Cordell HJ114
  83. Damman JJ116
  84. Davies G63, 66
  85. De Geus EJ20
  86. De Mutsert R40
  87. Deelen J41
  88. Demirkale Y32
  89. Doney ASF98
  90. Dorr M44, 46
  91. Farrall M56, 57
  92. Ferreira T56
  93. Franberg M21, 22, 117
  94. Gao H90
  95. Giedraitis V118
  96. Gieger C119
  97. Giulianini F16
  98. Gow AJ63, 120
  99. Hamsten A21, 22
  100. Harris TB121
  101. Hofman A17, 122
  102. Holliday EG104
  103. Hui J107, 108, 109, 110
  104. Jarvelin MR91, 123, 124, 125
  105. Johansson A84
  106. Johnson AD11, 126
  107. Jousilahti P69
  108. Jula A69
  109. Kahonen M127, 128
  110. Kathiresan S129, 130, 132
  111. Khaw KT133
  112. Kolcic I134
  113. Koskinen S69
  114. Langenberg C58
  115. Larson M11
  116. Launer LJ121
  117. Lehne B90
  118. Liewald DCM63, 66
  119. Lin L135
  120. Lind L136
  121. Mach F135
  122. Mamasoula C115
  123. Menni C13
  124. Mifsud B14
  125. Milaneschi Y138
  126. Morgan A74
  127. Morris AD139
  128. Morrison AC140
  129. Munson PJ32
  130. Nandakumar P28
  131. Nguyen QT32
  132. Nutile T80
  133. Oldehinkel AJ5
  134. Oostra BA18
  135. Org E23
  136. Padmanabhan S65, 141
  137. Palotie A143
  138. Pare G144
  139. Pattie A66
  140. Penninx BWJH138
  141. Poulter N92
  142. Pramstaller PP75, 145, 146
  143. Raitakari OT147, 148
  144. Ren M14, 149
  145. Rice K49
  146. Ridker PM16, 150
  147. Riese H5
  148. Ripatti S143
  149. Robino A151
  150. Rotter JI35
  151. Rudan I62
  152. Saba Y152
  153. Saint Pierre A75, 153
  154. Sala CF71
  155. Sarin AP143
  156. Schmidt R59, 61, 152
  157. Scott R104, 154, 155
  158. Seelen MA4
  159. Shields DC83
  160. Siscovick D156
  161. Sorice R80, 157
  162. Stanton A158
  163. Stott DJ142
  164. Sundstrom J136
  165. Swertz M6
  166. Taylor KD159, 160
  167. Thom S93
  168. Tzoulaki I90
  169. Tzourio C102, 103, 161
  170. Uitterlinden AG17, 19
  171. Volker U45, 46
  172. Vollenweider P163
  173. Wild S62
  174. Willemsen G20
  175. Wright AF87
  176. Yao J34
  177. Theriault S144
  178. Conen D164
  179. Attia J104, 154, 155
  180. Sever P94
  181. Debette S102, 103, 162
  182. Mookkanamori DO40, 42
  183. Zeggini E101
  184. Spector TD13
  185. Van Der Harst P7
  186. Palmer CNA98
  187. Vergnaud AC90
  188. Loos RJF58, 77, 78
  189. Polasek O134
  190. Starr JM63, 67
  191. Girotto G73, 74
  192. Hayward C65, 68
  193. Kooner JS95, 112, 165
  194. Lindgren CM27, 56
  195. Vitart V87
  196. Samani NJ2, 86
  197. Tuomilehto J70, 166, 167, 168
  198. Gyllensten U84
  199. Knekt P69
  200. Deary IJ63, 66
  201. Ciullo M80, 157
  202. Elosua R79
  203. Keavney BD169
  204. Hicks AA75
  205. Scott RA58
  206. Gasparini P73, 74
  207. Laan M24
  208. Liu Y170
  209. Watkins H56, 57
  210. Hartman CA5
  211. Salomaa V69
  212. Toniolo D71
  213. Perola M25, 69, 143
  214. Wilson JF62, 87
  215. Zhao JH58
  216. Lehtimaki T54, 55
  217. Van Duijn CM18
  218. Gudnason V52, 53
  219. Psaty BM48, 50, 51, 171
  220. Peters A47
  221. Rettig R172
  222. James A111, 173
  223. Jukema JW38
  224. Strachan DP174
  225. Palmas W175
  226. Metspalu A23
  227. Ingelsson E137, 176
  228. Boomsma DI20
  229. Franco OH17
  230. Bochud M36
  231. Newtoncheh C27, 129, 131, 132
  232. Munroe PB14, 15
  233. Elliott P91
  234. Chasman DI16, 150
  235. Chakravarti A28
  236. Knight J177
  237. Morris AP56, 178
  238. Levy D29, 33
  239. Tobin MD1
  240. Snieder H3
  241. Caulfield MJ14, 15
  242. Ehret GB28, 135

Source: Hypertension Published:2017


Abstract

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation. © 2017 American Heart Association, Inc.
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