Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury
Mohammadreza Rouini
Mohammadreza Rouini

Professor of Pharmaceutics

Department Pharmaceutics

School of Pharmacy

Medicinal Plants Research Center

Tehran University of Medical Sciences

All Documents
1. Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet Hcl Nanoparticles, Pharmaceutical Sciences (2024)
2. Association Between the Post-Mortem and Poisoning Concentration of Tramadol and Its Main Metabolite and Genotype of Cyp2d6, Pharmaceutical Chemistry Journal (2023)
3. Designing a Topical Nanoliposomal Formulation of Ruxolitinib Phosphate, Pharmaceutical Sciences (2023)
4. Development and Validation of an Analytical Rp-Hplc Method for Simultaneous Estimation of Losartan and Its Active Metabolite (Exp-3174) in Isolated Perfused Rat Liver, Current Pharmaceutical Analysis (2023)
5. Engineered Plga Microspheres for Extended-Release of Naltrexone: In Vitro, In Vivo, and Ivivr, Pharmaceutical Development and Technology (2023)
6. Evaluation of Important Human Cyp450 Isoforms and P-Glycoprotein Phenotype Changes and Genotype in Type 2 Diabetic Patients, Before and After Intensifying Treatment Regimen Using Geneva Cocktail, Basic and Clinical Pharmacology and Toxicology (2023)
7. Fundamentals and Applications of Isolated Perfused Lung (Ipl) Model in the Development of Pulmonary Drug Delivery, Current Drug Delivery (2023)
8. Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-Glycoprotein Activity Using the Geneva Cocktail Approach, Journal of Personalized Medicine (2023)
9. Metabolic Modeling-Based Drug Repurposing in Statin: An Overview of Mechanistic Approaches in the Management of Craniocerebral Trauma, Journal of Cellular and Molecular Anesthesia (2023)
10. Preparation of Polymersomes From Synthesized Hyaluronic Acid-Graft-Poly(Ε-Caprolactone) Copolymers for Drug Delivery to the Brain, Materials Today Chemistry (2023)
11. Screening of Cyclodextrins in the Processing of Buserelin Dry Powders for Inhalation Prepared by Spray Freeze-Drying, Advanced Pharmaceutical Bulletin (2023)
12. A Repurposed Drug Screen for Regulating Metabolic Disease: An Overview in the Management of Traumatic Brain Injury; [Una Deteccion De Drogas Reutilizada Para Regular La Enfermedad Metabolica: Una Descripcion General En El Manejo De La Lesion Cerebral Traumatica], Revista Latinoamericana de Hipertension (2022)
13. Can Intra-Abdominal Pressure Predict the Pharmacokinetics of Aminoglycosides in Critically Ill Patients With Intra-Abdominal Sepsis?, American Journal of Therapeutics (2022)
14. Current Status of Transarterial Chemoembolization (Tace) Agents in Hepatocellular Carcinoma Treatment, Journal of Drug Delivery Science and Technology (2022)
15. Efficacy Assessments of Tretinoin-Loaded Nano Lipid Carriers in Acne Vulgaris: A Double Blind, Split-Face Randomized Clinical Study, Archives of Dermatological Research (2022)
16. Evaluation of Amikacin Dosing Schedule in Critically Ill Elderly Patients With Different Stages of Renal Dysfunction, European Journal of Hospital Pharmacy (2022)
17. Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury, Acta Medica Iranica (2022)
18. Evaluation of Tolerability and Efficacy of a Topical Emulgel Containing Nanoliposomal Ruxolitinib Phosphate in the Treatment of Mild Atopic Dermatitis: A Before-After Single Group Pilot Study, Journal of Dermatological Treatment (2022)
19. Pharmacokinetic Study of High-Dose Oral Rifampicin in Critically Ill Patients With Multidrug-Resistant Acinetobacter Baumannii Infection, DARU# Journal of Pharmaceutical Sciences (2022)
20. Relationship Between Amikacin Pharmacokinetics and Biological Parameters Associated With Organ Dysfunction: A Case Series Study of Critically Ill Patients With Intra-Abdominal Sepsis, European Journal of Hospital Pharmacy (2022)
21. Study the Effect of 3,4-Methylenedioxy Methamphetamine on Cytochrome P450 2E1 Activity, Brazilian Journal of Pharmaceutical Sciences (2022)
22. Variations in the Frequencies of Polymorphisms in the Cyp450s Genes in Eight Major Ethnicities of Iran: A Review of the Human Data, Journal of Personalized Medicine (2022)
23. Evaluation of Cinnamon (Cinnamomum Verum) Effects on Liver Cyp450 2D1 Activity and Hepatic Clearance in Diabetic Rats, Jundishapur Journal of Natural Pharmaceutical Products (2021)
24. Evaluation of Phenoconversion Phenomenon in Obese Patients: The Effects of Bariatric Surgery on the Cyp450 Activity “A Protocol for a Case–Control Pharmacokinetic Study”, Journal of Diabetes and Metabolic Disorders (2021)
25. Frequency of Important Cyp450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison With Other Major Populations: A Comprehensive Review of the Human Data, Journal of Personalized Medicine (2021)
26. Investigation of Mdma Inhibitory Effect on Cytochrome P450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol, Advanced Pharmaceutical Bulletin (2021)
27. Preparation and Evaluation of Vancomycin Spray-Dried Powders for Pulmonary Delivery, Pharmaceutical Development and Technology (2021)
28. Preparation and Pulsatile Release Evaluation of Teriparatide-Loaded Multilayer Implant Composed of Polyanhydride-Hydrogel Layers Using Spin Coating for the Treatment of Osteoporosis, Journal of Pharmaceutical Innovation (2021)
29. Area Under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement, Critical Care Research and Practice (2020)
30. Assessment of Tramadol Pharmacokinetics in Correlation With Cyp2d6 and Clinical Symptoms, Drug Metabolism and Personalized Therapy (2020)
31. Bucladesine Attenuates Spatial Learning and Hippocampal Mitochondrial Impairments Induced by 3, 4-Methylenedioxymethamphetamine (Mdma), Neurotoxicity Research (2020)
32. Can Combination Therapy With Insulin and Metformin Improve Metabolic Function of the Liver, in Type I Diabetic Patients? an Animal Model Study on Cyp2d1 Activity, Journal of Diabetes and Metabolic Disorders (2020)
33. Dose Concentration and Spatial Memory and Brain Mitochondrial Function Association After 3,4-Methylenedioxymethamphetamine (Mdma) Administration in Rats, Archives of Toxicology (2020)
34. Effect of 3,4-Methylenedioxymethamphetamine on Liver Cyp2c19 Enzyme Activity in Isolated Perfused Rat Liver Using Omeprazole Probe, Journal of Mazandaran University of Medical Sciences (2020)
35. Evaluating the Effect of Type 2 Diabetes Mellitus on Cyp450 Enzymes and P-Gp Activities, Before and After Glycemic Control: A Protocol for a Case–Control Pharmacokinetic Study, MethodsX (2020)
36. Evaluation of Amikacin Pharmacokinetics in Critically Ill Patients With Intra-Abdominal Sepsis, Advanced Pharmaceutical Bulletin (2020)
37. Evaluation of Changes in Cytochrome P450 2C19 Activity in Type 2 Diabetic Rats Before and After Treatment, by Using Isolated Perfused Liver Model, Iranian Journal of Basic Medical Sciences (2020)
38. Evaluation of Epithelial Lining Fluid Concentration of Amikacin in Critically Ill Patients With Ventilator-Associated Pneumonia, Journal of Intensive Care Medicine (2020)
39. Evaluation of Hepatic Cyp2d1 Activity and Hepatic Clearance in Type I and Type Ii Diabetic Rat Models, Before and After Treatment With Insulin and Metformin, DARU# Journal of Pharmaceutical Sciences (2020)
40. Improving the In-Vivo Biological Activity of Fingolimod Loaded Phbv Nanoparticles by Using Hydrophobically Modified Alginate, Drug Development and Industrial Pharmacy (2020)
41. Pharmacokinetics and Bioequivalence Studies of Teriflunomide in Healthy Iranian Volunteers, Clinical Pharmacology in Drug Development (2020)
42. The Effect of Metal Salts on Aerosol Performance of Spray Dried Carrier-Free Formulations of Levofloxacin, DARU# Journal of Pharmaceutical Sciences (2020)
43. A Randomized Controlled Trial on the Efficacy, Safety, and Pharmacokinetics of Metformin in Severe Traumatic Brain Injury, Journal of Neurology (2019)
44. Pharmacokinetic Changes of Tramadol in Rats With Hepatotoxicity Induced by Ethanol and Acetaminophen in Perfused Rat Liver Model, Alcohol (2019)
45. The Effect of Surface Treatment on the Brain Delivery of Curcumin Nanosuspension: In Vitro and in Vivo Studies, International Journal of Nanomedicine (2019)
46. Assessment of Cyp2d6 Re-Activation After Inhibitory Effect of Mdma Using Tramadol As a Probe, Drug Metabolism and Personalized Therapy (2018)
47. Changes in Cyp2d Enzyme Activity Following Induction of Type 2 Diabetes, and Administration of Cinnamon and Metformin: An Experimental Animal Study, Xenobiotica (2018)
48. Correlation Between Plasma Concentrations of Tramadol and Its Metabolites and the Incidence of Seizure in Tramadol-Intoxicated Patients, Drug Metabolism and Personalized Therapy (2018)
49. Effect of Ph and Leucine Concentration on Aerosolization Properties of Carrier-Free Formulations of Levofloxacin, European Journal of Pharmaceutical Sciences (2018)
50. Gender Dependency in Streoselective Pharmacokinetics of Tramadol and Its Phase I Metabolites in Relation to Cyp2d6 Phenotype in Iranian Population, Iranian Journal of Pharmaceutical Research (2018)
51. Glutathione Conjugated Polyethylenimine on the Surface of Fe 3 O 4 Magnetic Nanoparticles As a Theranostic Agent for Targeted and Controlled Curcumin Delivery, Journal of Biomaterials Science# Polymer Edition (2018)
52. Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2018)
53. Prevalence of Candidemia and Associated Candida Subtypes Following Severe Sepsis in Non-Neutropenic Critically Ill Patients, Acta Biomedica (2018)
54. Simultaneous Electrochemical Determination of Isoniazid and Ethambutol Using Poly-Melamine/Electrodeposited Gold Nanoparticles Modified Pre-Anodized Glassy Carbon Electrode, Ionics (2018)
55. A Disposition Kinetic Study of Tramadol in Bile Duct Ligated Rats in Perfused Rat Liver Model, Biomedicine and Pharmacotherapy (2017)
56. Brain Delivery of Baclofen As a Hydrophilic Drug by Nanolipid Carriers: Characteristics and Pharmacokinetics Evaluation, Journal of Drug Delivery Science and Technology (2017)
57. Effect of Cyp2d6 Polymorphisms on the Pharmacokinetics of Propafenone and Its Two Main Metabolites; [Effet De Polymorphismes Cyp2d6 Sur La Pharmacocinetique De La Propafenone Et Ses Deux Metabolites Principaux], Therapie (2017)
58. Evaluation of the Ecstasy Influence on Tramadol and Its Main Metabolite Plasma Concentration in Rats, Drug Metabolism and Personalized Therapy (2017)
59. Evaluation of the Effects of Local Application of Thyme Honey in Open Cutaneous Wound Healing, Iranian Journal of Public Health (2017)
60. Inhibition of Mirtazapine Metabolism by Ecstasy (Mdma) in Isolated Perfused Rat Liver Model, DARU# Journal of Pharmaceutical Sciences (2017)
61. Mitochondrial Impairments Contribute to Spatial Learning and Memory Dysfunction Induced by Chronic Tramadol Administration in Rat: Protective Effect of Physical Exercise, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
62. Pharmaceutical Wastewater Treatment Using Membrane Bioreactor-Ozonation System, Water and Environment Journal (2017)
63. Scale up and Pharmacokinetic Study of a Novel Mutated Chimeric Tissue Plasminogen Activator (Mt-Pa) in Rats, Scientific Reports (2017)
64. Systemic Delivery of Parathyroid Hormone (1–34) Using Spray Freeze-Dried Inhalable Particles, Pharmaceutical Development and Technology (2017)
65. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial, Critical Care Research and Practice (2016)
66. Achievement of Vancomycin Therapeutic Goals in Critically Ill Patients: Early Individualization May Be Beneficial, Critical Care Research and Practice (2016)
67. Assays for Mdma and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse (2016)
68. Assays for Mdma and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants# Club and Dissociative Drugs# Hallucinogens# Steroids# Inhalants and International Aspects (2016)
69. Assays for Tramadol and Its Metabolites, Neuropathology of Drug Addictions and Substance Misuse Volume 3: General Processes and Mechanisms# Prescription Medications# Caffeine and Areca# Polydrug Misuse# Emerging Addictions and Non-Drug Addictions (2016)
70. Clinical Effects of Topical Antifungal Therapy in Chronic Rhinosinusitis: A Randomized, Double-Blind, Placebo-Controlled Trial of Intranasal Fluconazole, EXCLI Journal (2016)
71. Evaluation of the Route Dependency of the Pharmacokinetics and Neuro-Pharmacokinetics of Tramadol and Its Main Metabolites in Rats, European Journal of Pharmaceutical Sciences (2016)
72. Imatinib Metabolism and Disposition in Isolated Rat Perfused Liver, Iranian Journal of Pharmaceutical Sciences (2016)
73. Inhaled Sildenafil Nanocomposites: Lung Accumulation and Pulmonary Pharmacokinetics*, Pharmaceutical Development and Technology (2016)
74. Population Pharmacokinetic Analysis of the Oral Absorption Process and Explaining Intra-Subject Variability in Plasma Exposures of Imatinib in Healthy Volunteers, European Journal of Drug Metabolism and Pharmacokinetics (2016)
75. Protective Effects of Physical Exercise on Mdma-Induced Cognitive and Mitochondrial Impairment, Free Radical Biology and Medicine (2016)
76. Synergistic Effect of Honey and Propolis on Cutaneous Wound Healing in Rats, Acta Medica Iranica (2016)
77. The Effect of Excipients on the Stability and Aerosol Performance of Salmon Calcitonin Dry Powder Inhalers Prepared Via the Spray Freeze Drying Process, Acta Pharmaceutica (2016)
78. Tramadol, Usage, Misuse, and Addiction Processes, Neuropathology of Drug Addictions and Substance Misuse Volume 3: General Processes and Mechanisms# Prescription Medications# Caffeine and Areca# Polydrug Misuse# Emerging Addictions and Non-Drug Addictions (2016)
79. Transforming Growth Factor-Β (Tgf-Β) Activation in Cutaneous Wounds After Topical Application of Aloe Vera Gel, Canadian Journal of Physiology and Pharmacology (2016)
80. Effects of Cyclosporine a on the Hepatobiliary Disposition and Hepatic Uptake of Etoposide in an Isolated Perfused Rat Liver Model, Cancer Chemotherapy and Pharmacology (2015)
81. Genotype and Allele Frequency of Cyp2c19*17 in a Healthy Iranian Population, Medical Journal of the Islamic Republic of Iran (2015)
82. Histological Study of Wound Repair With Topical Aloe Vera Gel in Rat, Tehran University Medical Journal (2015)
83. Neuropharmacokinetic Evaluation of Methotrexate-Loaded Chitosan Nanogels, International Journal of Biological Macromolecules (2015)
84. The Effect of Thyme Honey Nasal Spray on Chronic Rhinosinusitis: A Double-Blind Randomized Controlled Clinical Trial, European Archives of Oto-Rhino-Laryngology (2015)