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Smart Bio-Encapsulation for Immunotherapy Publisher



Nasery MM1 ; Abadi B2, 3, 7 ; Seyedpour N1, 4 ; Bazdar P5, 6 ; Eslaminejad T2, 7
Authors
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Authors Affiliations
  1. 1. Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Brain Cancer Research Core (BCRC), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Smart Nanomaterials for Bioencapsulation Published:2022


Abstract

Immunotherapy is considered a promising strategy in cancer treatment that has achieved auspicious clinical outcomes in various cancer malignancies. Despite all the advances in immunotherapy, there is much to do to improve the efficiency and decrease the side effects of immunotherapy. To improve the safety and efficacy of immunotherapy, excellent delivery technologies by leveraging biomaterials can be incorporated into immunotherapy to accomplish specific immune-activation in the tumor tissue and overcome immunosuppression in the tumor microenvironment. Therefore, biomaterial-based drug delivery systems can enhance antitumor immunity while decreasing immune-related adverse effects. In addition, they provide co-delivery of different therapeutic cargos, leading to more precise and efficient cancer treatment. This chapter provides an overview of current cancer immunotherapy strategies and how bionanomaterials (lipid-based nanoparticles, polymeric nanoparticles, exosomes, DNA origami, and metallic nanoparticles) can mitigate immunotherapy limitations and enhance the efficiency of these strategies. © 2022 Elsevier Inc. All rights reserved.
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