Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Sulfamic Acid-Functionalized Hydroxyapatite-Encapsulated Γ-Fe2o3 Nanoparticles As a Magnetically Recoverable Catalyst for Synthesis of N-Fused Imidazole-Quinoline Conjugates Under Solvent-Free Conditions Publisher



Mouradzadegun A1 ; Mamani L2 ; Mahdavi M3 ; Rashid Z4 ; Shafiee A3 ; Foroumadi A3 ; Dianat S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran
  2. 2. Nanotechnology Department, Agricultural Biotechnology Research Institute of Iran (ABRII), Karaj, Iran
  3. 3. Department of Medical Chemistry, Faculty of Pharmacy, Pharmaceutical Science Research Center, Tehran University of Medical Sciences, 14176, Tehran, Iran
  4. 4. Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Source: RSC Advances Published:2015


Abstract

Novel conjugated imidazo[1,2-a]pyridine and imidazo[2,1-b]thiazol-quinoline derivatives were synthesized through a one-pot condensation reaction of 2-chloro-3-formyl-quinoline, isocyanides and various amidines in the presence of catalytic amounts of sulfamic acid-functionalized γ-Fe2O3 nanoparticles encapsulated by hydroxyapatite (denoted as [γ-Fe2O3-HAp-(CH2)3-NHSO3H]) under solvent-free conditions. A series of N-fused 2-(2-chloro-quinolin-3-yl)-3-aminoimidazole derivatives were obtained in high to excellent yields using a mild and environmentally benign protocol by applying [γ-Fe2O3-HAp-(CH2)3-NHSO3H] as an efficient magnetically recoverable Bronsted acid catalyst. It is notable that the catalyst could be easily recovered and reused without any significant loss of its performance and activity. © The Royal Society of Chemistry.