Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives

Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives Publisher

Najafi Z¹ ; Mahdavi M² ; Safavi M³ ; Saeedi M² ; Alinezhad H⁴ ; Pordeli M⁵ ; Kabudanian Ardestani S⁵ ; Shafiee A² ; Foroumadi A² ; Akbarzadeh T^{1, 6}

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran
2. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran
3. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran
4. Faculty of Chemistry, Mazandaran University, Babolsar, Iran
5. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
6. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2015

Abstract

New derivatives of triazole-isoxazole were synthesized through a four-step reaction starting from various ethyl 4-aryl-2,4-dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF-7 and T-47D). © 2014 HeteroCorporation.

Style	Citing Format
MLA	Najafi Z, et al.. "Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives." Journal of Heterocyclic Chemistry, vol. 52, no. 6, 2015, pp. 1743-1747.
APA	Najafi Z, Mahdavi M, Safavi M, Saeedi M, Alinezhad H, Pordeli M, Kabudanian Ardestani S, Shafiee A, Foroumadi A, Akbarzadeh T (2015). Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives. Journal of Heterocyclic Chemistry, 52(6), 1743-1747.
Chicago	Najafi Z, Mahdavi M, Safavi M, Saeedi M, Alinezhad H, Pordeli M, Kabudanian Ardestani S, Shafiee A, Foroumadi A, Akbarzadeh T. "Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives." Journal of Heterocyclic Chemistry 52, no. 6 (2015): 1743-1747.
Harvard	Najafi Z et al. (2015) 'Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives', Journal of Heterocyclic Chemistry, 52(6), pp. 1743-1747.
Vancouver	Najafi Z, Mahdavi M, Safavi M, Saeedi M, Alinezhad H, Pordeli M, et al.. Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives. Journal of Heterocyclic Chemistry. 2015;52(6):1743-1747.
BibTex	@article{ author = {Najafi Z and Mahdavi M and Safavi M and Saeedi M and Alinezhad H and Pordeli M and Kabudanian Ardestani S and Shafiee A and Foroumadi A and Akbarzadeh T}, title = {Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives}, journal = {Journal of Heterocyclic Chemistry}, volume = {52}, number = {6}, pages = {1743-1747}, year = {2015} }
RIS	TY - JOUR AU - Najafi Z AU - Mahdavi M AU - Safavi M AU - Saeedi M AU - Alinezhad H AU - Pordeli M AU - Kabudanian Ardestani S AU - Shafiee A AU - Foroumadi A AU - Akbarzadeh T TI - Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives JO - Journal of Heterocyclic Chemistry VL - 52 IS - 6 SP - 1743 EP - 1747 PY - 2015 ER -

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