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An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers Publisher Pubmed



Farzaneh M1 ; Masoodi T2 ; Ghaedrahmati F3 ; Radoszkiewicz K4 ; Anbiyaiee A5 ; Sheykhisabzehpoush M6 ; Rad NK7 ; Uddin S8 ; Jooybari SPM9 ; Khoshnam SE10, 11 ; Azizidoost S12
Authors
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Authors Affiliations
  1. 1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, Doha, 26999, Qatar
  3. 3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Poland
  5. 5. Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. epartment of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  8. 8. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar
  9. 9. Department of Biology, Faculty of Basic Sciences and Engineering, University of Gonbad Kavous, Golestan, Gonbad Kavus, Iran
  10. 10. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  11. 11. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  12. 12. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Long non-coding RNAs (lncRNAs) present pivotal roles in cancer tumorigenesis and progression. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1) as a lncRNA has been shown to mediate cell proliferation, migration, and EMT in tumor cells. NEAT1 by targeting several miRNAs/mRNA axes could regulate cancer cell behavior. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of some human cancers. In this review, we summarized various NEAT1-related signaling pathways that are critical in cancer initiation and progression. © 2023
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