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The Regenerative Potential of Glial Progenitor Cells and Reactive Astrocytes in Cns Injuries Publisher Pubmed



Kiaie N1 ; Gorabi AM2 ; Loveless R3 ; Teng Y4 ; Jamialahmadi T5, 6 ; Sahebkar A5, 7, 8
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, 30912, GA, United States
  4. 4. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, United States
  5. 5. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Neuroscience and Biobehavioral Reviews Published:2022


Abstract

Cell therapeutic approaches focusing on the regeneration of damaged tissue have been a popular topic among researchers in recent years. In particular, self-repair scarring from the central nervous system (CNS) can significantly complicate the treatment of an injured patient. In CNS regeneration schemes, either glial progenitor cells or reactive glial cells have key roles to play. In this review, the contribution and underlying mechanisms of these progenitor/reactive glial cells during CNS regeneration are discussed, as well as their role in CNS-related diseases. © 2022 Elsevier Ltd
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