Radiofrequency Electric Field Hyperthermia With Gold Nanostructures: Role of Particle Shape and Surface Chemistry Publisher Pubmed



Amini SM^{1, 2} ; Kharrazi S¹ ; Rezayat SM^{1, 3, 4} ; Gilani K^{5, 6}
Source: Artificial Cells# Nanomedicine and Biotechnology Published:2018

Abstract

Hyperthermia treatment of cancerous cells has been recently developed drastically with the help of nanostructures. Heating of gold nanoparticles in non-invasive radiofrequency electric field (RF-EF) is a promising and unique technique for cancer hyperthermia. However, because of differences between particles (i.e. their surface chemistry and dispersion medium) and between RF-EF sources, the research community has not reached a consensus yet. Here, we report the results of investigations on heating of gold nanoparticles and gold nanorods under RF-EF and feasibility of in-vitro cancer hyperthermia. The heating experiments were performed to investigate the role of particle shape and surface chemistry (CTAB, citrate and PEG molecules). In-vitro hyperthermia was performed on human pancreatic cancer cell (MIA Paca-2) with PEG-coated GNPs and GNRs at concentrations that were found non-toxic based on the results of cytotoxicity assay. Application of RF-EF on cells treated with PEG-GNPs and PEG-GNRs proved highly effective in killing cells. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.