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Nanofibrillated Chitosan Coated Highly Ordered Titania Nanotubes Array/Graphene Nanocomposite With Improved Biological Characters Publisher Pubmed



Rahnamaee SY1, 2 ; Bagheri R2 ; Heidarpour H3 ; Vossoughi M3, 4 ; Golizadeh M3 ; Samadikuchaksaraei A5, 6, 7
Authors
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Authors Affiliations
  1. 1. Institute for Nanoscience & Nanotechnology (INST), Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran
  2. 2. Polymeric Materials Research Group (PMRG), Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran
  3. 3. Institute for Biotechnology and Environment (IBE), Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran
  4. 4. Chemical and Petroleum Engineering Department, Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran
  5. 5. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, P.O. Box 14496-14535, Tehran, Iran
  7. 7. Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, P.O. Box 14496-14535, Tehran, Iran

Source: Carbohydrate Polymers Published:2021


Abstract

Designing multifunctional surfaces is key to develop advanced materials for orthopedic applications. In this study, we design a double-layer coating, assembled onto the completely regular titania nanotubes (cRTNT) array. Benefiting from the biological and topological characteristics of chitosan nanofibers (CH) and reduced graphene oxide (RGO) through a unique assembly, the designed material features promoted osteoblast cell viability, prolonged antibiotic release profile, as well as inhibited bacterial biofilm formation. The synergistic effect of RGO and CH on the biological performance of the surface is investigatSed. The unique morphology of the nanofibers leads to the partial coverage of RGO-modified nanotubes, providing an opportunity to access the sublayer properties. Another merit of this coating lies in its morphological similarity to the extracellular matrix (ECM) to boost cellular performance. According to the results of this study, this platform holds promising advantages over the bare and bulk biopolymer-modified TNTs. © 2020 Elsevier Ltd
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