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Peptide and Protein Vaccines for Cancer Publisher



Keshavarzfathi M1, 2, 3 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2018


Abstract

Tumor antigens are the basis of most cancer vaccine strategies and other types of specific cancer immunotherapy. They are targeted by application of various approaches, and using the peptides containing the epitope(s) of a tumor antigen benefits form an standard and easy method to evoke anticancer immunity. However, some drawbacks are attributed to this simple method, which limit its usage unless optimization is undertaken. In this chapter, peptide- and protein-based vaccines against many types of cancer will be reviewed. Results of the clinical trials, advantages and disadvantages, and some suggestions to optimize peptide-based vaccine toward its pervasive usage will be provided. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd All rights reserved.
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