Cellular Dust As a Novel Hope for Regenerative Cancer Medicine Publisher Pubmed



Hosseini MS^{1, 10} ; Roudsari PP^{1, 10} ; Gilany K^{2, 3, 4} ; Goodarzi P⁵ ; Payab M⁶ ; Tayanloobeik A^{7, 9} ; Larijani B⁸ ; Arjmand B^{1, 7, 9, 10}
Source: Advances in Experimental Medicine and Biology Published:2020

Abstract

Although stem cells have the most therapeutic potential, the advantages of regenerative medicine may be best provided using extracellular vesicles which also known in the past as “cellular dust.” These microparticles are substances released by cells and play a pivotal role in pathophysiology of tumor progression and metastasis, thrombosis, and inflammation. Extracellular vesicles including exosomes and cell-derived microparticles supporting many physiological and disease processes which are relevant to immunology, hemostasis, thrombosis, neurobiology, cell signaling, angiogenesis, and cancer. While they have not any value for many years, this cellular dust has been studied and shows therapeutic properties similar to their mother cells (stem cells) but without their disadvantages. These vesicles do not divide, limiting the risk of cancer, and do not differentiate either. Therefore, they prevent tumor progression and development of poor function. Furthermore, it appears that they can be produced by a single donor for several patients, and have already confirmed their therapeutic potential in animals in repairing heart, liver and kidney lesions. The present study was aimed to introduce cellular dust as a new horizon for regenerative cancer medicine and also new hope for potential therapeutic applications of cancer and associated diseases. © Springer Nature Switzerland AG 2020.