Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Silver Sulfadiazine Nanoethogel for Burn Healing: Characterization and Investigation of Its in Vivo Effects Publisher Pubmed



Razavi S1 ; Partoazar A2 ; Takzaree N3 ; Fasihiramandi M4 ; Bahador A5 ; Darvishi MH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Nanobiotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2018


Abstract

Aim: Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries. Materials & methods: Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD. Results: The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of-67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSD ethosomal gel while untreated group showed 59.41%. Conclusion: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment. © 2018 Future Medicine Ltd.
Related Docs
1. New Concepts in Wound Targeting Through Liposome-Based Nanocarriers (Lbns), Journal of Drug Delivery Science and Technology (2022)
2. Evaluation of Propylene Glycol Nanoliposomes Containing Curcumin on Burn Wound Model in Rat: Biocompatibility, Wound Healing, and Anti-Bacterial Effects, Drug Delivery and Translational Research (2017)
3. Promotion of Burn Wound Healing by Local Application of Adipose- Derived Mesenchymal Stem Cells: An Experimental Study, Medical Journal of the Islamic Republic of Iran (2021)
4. Estimation of Anti-Inflammatory and Analgesic Effects of Topical Nanocen (Nanoliposomal Arthrocen) on Mice, AAPS PharmSciTech (2019)
5. Beneficial Effects of Rocen (Topical Nano-Arthrocen) on Atopic Dermatitis in Mice, BMC Complementary Medicine and Therapies (2021)
Experts (# of related papers)
View all Related Experts
Alireza Partoazar (4)
Ahmad Reza Dehpour (3)