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A Methodological Checklist for Fmri Drug Cue Reactivity Studies: Development and Expert Consensus Publisher Pubmed



Ekhtiari H1, 2 ; Zarebidoky M3, 4 ; Sangchooli A3 ; Janes AC5 ; Kaufman MJ5 ; Oliver JA6, 7, 8 ; Prisciandaro JJ9 ; Wustenberg T10 ; Anton RF9 ; Bach P11 ; Baldacchino A12 ; Beck A10, 13 ; Bjork JM14 ; Brewer J15 Show All Authors
Authors
  1. Ekhtiari H1, 2
  2. Zarebidoky M3, 4
  3. Sangchooli A3
  4. Janes AC5
  5. Kaufman MJ5
  6. Oliver JA6, 7, 8
  7. Prisciandaro JJ9
  8. Wustenberg T10
  9. Anton RF9
  10. Bach P11
  11. Baldacchino A12
  12. Beck A10, 13
  13. Bjork JM14
  14. Brewer J15
  15. Childress AR16
  16. Claus ED17
  17. Courtney KE18
  18. Ebrahimi M3
  19. Filbey FM19
  20. Ghahremani DG20
  21. Azbari PG3, 21
  22. Goldstein RZ22
  23. Goudriaan AE23
  24. Grodin EN20
  25. Hamilton JP24, 25
  26. Hanlon CA26
  27. Hassaniabharian P27
  28. Heinz A10
  29. Joseph JE28
  30. Kiefer F11
  31. Zonoozi AK3, 29
  32. Kober H30
  33. Kuplicki R1
  34. Li Q31
  35. London ED20
  36. Mcclernon J6
  37. Noori HR32, 33
  38. Owens MM34
  39. Paulus MP1
  40. Perini I24, 25
  41. Potenza M30, 35, 36, 37
  42. Potvin S38
  43. Ray L20
  44. Schacht JP39
  45. Seo D30
  46. Sinha R30
  47. Smolka MN40
  48. Spanagel R41
  49. Steele VR30
  50. Stein EA42
  51. Steinsloeber S43
  52. Tapert SF18
  53. Verdejogarcia A44
  54. Vollstadtklein S11
  55. Wetherill RR16
  56. Wilson SJ45
  57. Witkiewitz K46
  58. Yuan K47
  59. Zhang X48, 49
  60. Zilverstand A2
Show Affiliations
Authors Affiliations
  1. 1. Laureate Institute for Brain Research, Tulsa, OK, United States
  2. 2. Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States
  3. 3. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Shahid-Sadoughi University of Medical Sciences, Yazd, Iran
  5. 5. Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, United States
  6. 6. Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
  7. 7. TSET Health Promotion Research Center, Stephenson Cancer Center, Oklahoma City, OK, United States
  8. 8. Department of Psychiatry & Behavioral Sciences, Oklahoma State University Center for Health Sciences, Tulsa, OK, United States
  9. 9. Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States
  10. 10. Department of Psychiatry and Neurosciences, Charite Campus Mitte, Charite–Universitatsmedizin Berlin, Berlin, Germany
  11. 11. Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health (CIMH), Heidelberg University, Mannheim, Germany
  12. 12. Division of Population Studies and Behavioural Sciences, St Andrews University Medical School, University of St Andrews, United Kingdom
  13. 13. Faculty of Health, Health and Medical University, Campus Potsdam, Potsdam, Germany
  14. 14. Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, United States
  15. 15. Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, United States
  16. 16. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  17. 17. Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, United States
  18. 18. Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States
  19. 19. Center for BrainHealth, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States
  20. 20. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States
  21. 21. Department of Biomedical Engineering, Shahed University, Tehran, Iran
  22. 22. Departments of Psychiatry & Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  23. 23. Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam and Amsterdam Neuroscience, Amsterdam, Netherlands
  24. 24. Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden
  25. 25. Center for Medical Image Science and Visualization, Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden
  26. 26. Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, United States
  27. 27. Brain and Cognition Clinic, Institute for Cognitive Science Studies, Tehran, Iran
  28. 28. Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States
  29. 29. Mashhad University of Medical Sciences, Mashhad, Iran
  30. 30. Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States
  31. 31. Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, China
  32. 32. International Center for Primate Brain Research, Center for Excellence in Brain Science and Intelligence Technology (CEBSIT)/Institute of Neuroscience (ION), Chinese Academy of Sciences, Shanghai, China
  33. 33. McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States
  34. 34. Department of Psychiatry, University of Vermont, Burlington, VT, United States
  35. 35. Connecticut Mental Health Center, New Haven, CT, United States
  36. 36. Connecticut Council on Problem Gambling, Wethersfield, CT, United States
  37. 37. Department of Neuroscience, Child Study Center and Wu Tsai Institute, Yale School of Medicine, New Haven, CT, United States
  38. 38. Centre de recherche de l’Institut Universitaire en Sante Mentale de Montreal, University of Montreal, Montreal, Canada
  39. 39. University of Colorado Anschutz Medical Campus, Aurora, CO, United States
  40. 40. Department of Psychiatry, Technische Universitat Dresden, Dresden, Germany
  41. 41. Institute of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
  42. 42. Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, United States
  43. 43. Department of Clinical Psychology and Psychotherapy, Otto-Friedrich-University of Bamberg, Bamberg, Germany
  44. 44. Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia
  45. 45. Department of Psychology, The Pennsylvania State University, University Park, PA, United States
  46. 46. Department of Psychology, University of New Mexico, Albuquerque, NM, United States
  47. 47. School of Life Science and Technology, Xidian University, Xi’an, China
  48. 48. Department of Psychology, School of Humanities and Social Science, University of Science and Technology of China, Anhui, China
  49. 49. Department of Radiology, First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Science at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science and Technology of China, Anhui, China

Source: Nature Protocols Published:2022


Abstract

Cue reactivity is one of the most frequently used paradigms in functional magnetic resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have been promising results elucidating the neurocognitive mechanisms of SUDs and SUD treatments, the interpretability and reproducibility of these studies is limited by incomplete reporting of participants’ characteristics, task design, craving assessment, scanning preparation and analysis decisions in fMRI drug cue reactivity (FDCR) experiments. This hampers clinical translation, not least because systematic review and meta-analysis of published work are difficult. This consensus paper and Delphi study aims to outline the important methodological aspects of FDCR research, present structured recommendations for more comprehensive methods reporting and review the FDCR literature to assess the reporting of items that are deemed important. Forty-five FDCR scientists from around the world participated in this study. First, an initial checklist of items deemed important in FDCR studies was developed by several members of the Enhanced NeuroImaging Genetics through Meta-Analyses (ENIGMA) Addiction working group on the basis of a systematic review. Using a modified Delphi consensus method, all experts were asked to comment on, revise or add items to the initial checklist, and then to rate the importance of each item in subsequent rounds. The reporting status of the items in the final checklist was investigated in 108 recently published FDCR studies identified through a systematic review. By the final round, 38 items reached the consensus threshold and were classified under seven major categories: ‘Participants’ Characteristics’, ‘General fMRI Information’, ‘General Task Information’, ‘Cue Information’, ‘Craving Assessment Inside Scanner’, ‘Craving Assessment Outside Scanner’ and ‘Pre- and Post-Scanning Considerations’. The review of the 108 FDCR papers revealed significant gaps in the reporting of the items considered important by the experts. For instance, whereas items in the ‘General fMRI Information’ category were reported in 90.5% of the reviewed papers, items in the ‘Pre- and Post-Scanning Considerations’ category were reported by only 44.7% of reviewed FDCR studies. Considering the notable and sometimes unexpected gaps in the reporting of items deemed to be important by experts in any FDCR study, the protocols could benefit from the adoption of reporting standards. This checklist, a living document to be updated as the field and its methods advance, can help improve experimental design, reporting and the widespread understanding of the FDCR protocols. This checklist can also provide a sample for developing consensus statements for protocols in other areas of task-based fMRI. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
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