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Mno2-Tio2 Nanocomposite and 2-(3,4-Dihydroxyphenethyl) Isoindoline-1,3-Dione As an Electrochemical Platform for the Concurrent Determination of Cysteine, Tryptophan and Uric Acid Publisher



Bananezhad A1 ; Karimimaleh H2 ; Ganjali MR1, 3 ; Norouzi P1, 3
Authors

Source: Electroanalysis Published:2018


Abstract

A novel modified carbon paste electrode (CPE) based on an MnO2-TiO2 nanocomposite and 2-(3,4 dihydroxyphenethyl) isoindoline-1,3-dione (DPID) as the modifier for the simultaneous analysis of cysteine (Cys), tryptophan (Trp) and uric acid (UA), as three key biochemicals present in human body. The MnO2/TiO2 nanocomposite was synthesized through a chemical co-precipitation approach and the resulting electrode (MnO2-TiO2/DPID/CPE) was used for studying the electrochemical oxidation of cysteine (Cys), tryptophan (Trp) and uric acid. As opposed to conventional CPEs, the oxidation peak potential of cysteine on MnO2-TiO2/DPID/CPE had a 600.0 mV decrease in overpotential and could be observed at 30.0 mV, and the signals were linear from 0.025 to 200.0 μM, and a lower detection limit of 0.013 μM was reached. The MnO2-TiO2/DPID/CPE was satisfactorily used for the concurrent analysis of Cys, Trp and UA in pharmaceutical and biological samples. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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