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Facile Green Synthesis of Nio/Nico2o4 Nanocomposite As an Efficient Electrochemical Platform for Determination of Dopamine Publisher



Amiri M1, 2 ; Akbari Javar H3 ; Mahmoudimoghaddam H4, 5
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran
  2. 2. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Science, Kerman, Iran
  3. 3. Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Electroanalysis Published:2021


Abstract

The synthesis of NiO/NiCo2O4 nanoparticles by an eco-friendly, fast, simple and cost-effective approach employing Urtica extract is reported in this study. The NiO/NiCo2O4 nanocomposite were characterized using VSM, FTIR, XRD, and SEM techniques. Moreover, to construct a modified carbon paste electrode, NiO/NiCo2O4 were employed and this sensor was used for dopamine (DA) detection. Using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques, the electrochemical behavior of dopamine at the NiO/NiCo2O4/CPE was investigated. Analysis of dopamine, with a limit of detection (LOD) equal to 0.04 μM, in the concentration range of 0.1–100.0 μM, was facilitated by NiO/NiCo2O4/CPE. Moreover, the satisfactory selectivity for DA determination in the presence of uric acid (UA) and ascorbic acid (AA), was obtained. The suggested new sensor displayed a good reproducibility, sensitivity, and stability for determination of DA in drug and biological samples. © 2021 Wiley-VCH GmbH