Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial

Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial Publisher Pubmed

Pahlavani N^{1, 2, 3} ; Malekahmadi M^{4, 5} ; Sedaghat A⁶ ; Rostami A⁷ ; Alkadir OKA⁸ ; Taifi A⁹ ; Ranjbar G³ ; Sahebkar A^{10, 11} ; Abdelbasset WK^{12, 13} ; Beigmohammadi MT⁴ ; Mir M¹⁴ ; Bagheri Moghaddam A^{14, 15} ; Tabesh H¹⁶ ; Sadeghi O¹⁷ Show All Authors

Pahlavani N^{1, 2, 3}
Malekahmadi M^{4, 5}
Sedaghat A⁶
Rostami A⁷
Alkadir OKA⁸
Taifi A⁹
Ranjbar G³
Sahebkar A^{10, 11}
Abdelbasset WK^{12, 13}
Beigmohammadi MT⁴
Mir M¹⁴
Bagheri Moghaddam A^{14, 15}
Tabesh H¹⁶
Sadeghi O¹⁷
Gholizadeh Navashenaq J¹⁸
Firouzi S³
Fathi Najafi M¹⁹
Safarian M³
Ghayourmobarhan M^{20, 21}

Show Affiliations

1. Health Sciences Research Center, Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran
2. Department of Clinical Biochemistry and Nutrition, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4. Anesthesiology and Intensive Care Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
5. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
6. Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Internal Medicine, Faculty of General Medicine, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
8. Al-Nisour University College, Baghdad, Iraq
9. Al-Manara College for Medical Sciences, Al-Amarah, Iraq
10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
12. Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia
13. Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt
14. Department of Anesthesiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
15. Department of Internal Medicine and Critical Care, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
16. Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
17. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
18. Non-Communicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
19. Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, Iran
20. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
21. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Complementary Medicine Research Published:2022

Abstract

Background and Objective: The present study aimed to investigate the effects of propolis and melatonin supplementation on inflammation, clinical outcomes, and oxidative stress markers in patients with primary pneumosepsis. Materials and Methods: This pilot randomized controlled trial was conducted on 55 patients with primary pneumosepsis who were randomly assigned to the intervention and control groups. In the three intervention groups, the patients received propolis alone (1,000 mg/day), propolis (1,000 mg/day) plus melatonin (20 mg/day), and melatonin alone (20 mg/day). The control group received placebo. The inflammatory and oxidative stress markers as well as clinical outcomes were evaluated before and after the intervention, and the 28-day survival rate was also recorded. Results: After the intervention, the combination of propolis and melatonin significantly reduced interleukin-6 (-55.282 pg/mL) and C-reactive protein (-21.656 mg/L) levels, while increasing gavage intake (326.680 mL/day) and improving some clinical outcomes (APACHE II, SOFA, and NUTRIC scores) compared to the control group. However, no significant difference was observed between the groups in terms of oxidative stress and hematological indices. In addition, there was no significant difference in the 28-day survival rate between the groups (p = 0.07). Conclusion: Supplementation with propolis and melatonin may improve clinical outcomes by reducing inflammation. Further investigations are required to confirm these findings. © 2022 S. Karger AG. All rights reserved.

Related Docs

View other Related Docs

1. Effect of Propolis Supplementation on Oxidative Stress Markers: A Systematic Review of Randomized Controlled Trials, Journal of Herbal Medicine (2023)

2. Effects of Propolis and Melatonin on Oxidative Stress, Inflammation, and Clinical Status in Patients With Primary Sepsis: Study Protocol and Review on Previous Studies, Clinical Nutrition ESPEN (2019)

3. Propolis Efficacy on Sars-Cov Viruses: A Review on Antimicrobial Activities and Molecular Simulations, Environmental Science and Pollution Research (2022)

4. Evidence for the Benefits of Melatonin in Cardiovascular Disease, Frontiers in Cardiovascular Medicine (2022)

5. The Effects of Melatonin Supplementation on Mental Health, Metabolic and Genetic Profiles in Patients Under Methadone Maintenance Treatment, Addiction Biology (2019)

6. The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Renal Nutrition (2020)

7. High Dose Melatonin As an Adjuvant Therapy in Intubated Patients With Covid-19: A Randomized Clinical Trial, Journal of Taibah University Medical Sciences (2022)

8. The Effect of Melatonin Supplementation on Lipid Profile and Anthropometric Indices: A Systematic Review and Meta-Analysis of Clinical Trials, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)

Experts (# of related papers)

View all Related Experts

Mohammad Ali Mansournia (4)

Atabak Najafi (3)

Style	Citing Format
MLA	Pahlavani N, et al.. "Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial." Complementary Medicine Research, vol. 29, no. 4, 2022, pp. 275-285.
APA	Pahlavani N, Malekahmadi M, Sedaghat A, Rostami A, Alkadir OKA, Taifi A, Ranjbar G, Sahebkar A, Abdelbasset WK, Beigmohammadi MT, Mir M, Bagheri Moghaddam A, Tabesh H, Sadeghi O, Gholizadeh Navashenaq J, Firouzi S, Fathi Najafi M, Safarian M, Ghayourmobarhan M (2022). Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial. Complementary Medicine Research, 29(4), 275-285.
Chicago	Pahlavani N, Malekahmadi M, Sedaghat A, Rostami A, Alkadir OKA, Taifi A, Ranjbar G, et al.. "Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial." Complementary Medicine Research 29, no. 4 (2022): 275-285.
Harvard	Pahlavani N et al. (2022) 'Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial', Complementary Medicine Research, 29(4), pp. 275-285.
Vancouver	Pahlavani N, Malekahmadi M, Sedaghat A, Rostami A, Alkadir OKA, Taifi A, et al.. Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial. Complementary Medicine Research. 2022;29(4):275-285.
BibTex	@article{ author = {Pahlavani N and Malekahmadi M and Sedaghat A and Rostami A and Alkadir OKA and Taifi A and Ranjbar G and Sahebkar A and Abdelbasset WK and Beigmohammadi MT and Mir M and Bagheri Moghaddam A and Tabesh H and Sadeghi O and Gholizadeh Navashenaq J and Firouzi S and Fathi Najafi M and Safarian M and Ghayourmobarhan M}, title = {Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial}, journal = {Complementary Medicine Research}, volume = {29}, number = {4}, pages = {275-285}, year = {2022} }
RIS	TY - JOUR AU - Pahlavani N AU - Malekahmadi M AU - Sedaghat A AU - Rostami A AU - Alkadir OKA AU - Taifi A AU - Ranjbar G AU - Sahebkar A AU - Abdelbasset WK AU - Beigmohammadi MT AU - Mir M AU - Bagheri Moghaddam A AU - Tabesh H AU - Sadeghi O AU - Gholizadeh Navashenaq J AU - Firouzi S AU - Fathi Najafi M AU - Safarian M AU - Ghayourmobarhan M TI - Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients With Primary Pneumosepsis: A Randomized Controlled Clinical Trial JO - Complementary Medicine Research VL - 29 IS - 4 SP - 275 EP - 285 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract