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Plasmonic Photothermal Therapy of Colon Cancer Cells Utilising Gold Nanoshells: An in Vitro Study Publisher



Koohi SR1 ; Derakhshan MA1 ; Faridani F2 ; Nejad SM3 ; Amanpour S4 ; Tajerian R1 ; Yarmahmoodi M5 ; Faridimajidi R1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center of Sciences and Technologies in Medicine, Imam Khomeini Hospital, Tehran, Iran
  3. 3. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Centre of Biomedical Technology and Robotics (RCBTR), Tehran University of Medical Sciences, Tehran, Iran

Source: IET Nanobiotechnology Published:2018


Abstract

In this study, gold nanoshell (GNS) were synthesised utilising the Halas method. The obtained nanoparticles (NPs) were characterised by Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV–Vis spectroscopy and dynamic light scattering. FTIR spectra demonstrated the successful functionalisation of silica NP with 3-aminopropyl trimethoxysilane. SEM and TEM images showed the morphology and diameter of the synthesised silica NPs (137 ± 26 nm) and GNS. UV–Vis spectrum illustrated the maximum absorbance of the resultant GNS and their average hydrodynamic diameter was 159 nm. For in vitro study, HCT-116 cells were exposed to gold nanoshells and intense pulsed light in different experiment groups. The results showed that exposing the cells to nanoshells and 30 s irradiation would efficiently decrease the viability percentage of the cells to about 30% compared with the control. A continued exposure of 4 min decreased the viability of the cancer cells to 20%. The results demonstrated that photothermal therapy would be promising in treatment of colon cancer cells utilising gold nanoshells. © The Institution of Engineering and Technology 2017.
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