Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad

Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad Publisher Pubmed

Ramezani A^{1, 2} ; Koohdani F² ; Djazayeri A³ ; Nematipour E⁴ ; Keshavarz SA⁵ ; Sabooryaraghi AA² ; Eshraghian MR⁶ ; Yousefinejad A² ; Javanbakht H² ; Zarei M² ; Gholamhosseini S² ; Djalali M²

Show Affiliations

1. Department of Basic sciences and Nutrition, Mazandaran University of Medical Sciences, Sari, Iran
2. Departments of Molecular and Cellular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3. Departments of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
4. Departments of Cardiology, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
5. Departments of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
6. Departments of Biostatistics, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Anadolu Kardiyoloji Dergisi Published:2015

Abstract

Objective: Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD). Methods: This randomized, double-blind, placebo-controlled trial included 67 male patients with CAD. First of the four group of participants received 4 g/day omega-3 fatty acids plus 400 IU/day vitamin E (OE), second group 4 g/day omega-3 fatty acids plus vitamin E placebo (OP), or both omega-3 fatty acid and vitamin E placebos (PP) for 8 weeks. Adiponectin gene expression and serum adiponectin and FABP4 levels were evaluated. Results: The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. In the OP group, serum adiponectin levels did not change significantly. Consumption of omega-3 fatty acids with and without vitamin E had no significant effect on adiponectin gene expression. Conclusion: Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. This nutritional intervention may prevent complications in patients with CAD because of increased adiponectin levels. © 2015 by Turkish Society of Cardiology.

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Style	Citing Format
MLA	Ramezani A, et al.. "Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad." Anadolu Kardiyoloji Dergisi, vol. 15, no. 12, 2015, pp. 981-989.
APA	Ramezani A, Koohdani F, Djazayeri A, Nematipour E, Keshavarz SA, Sabooryaraghi AA, Eshraghian MR, Yousefinejad A, Javanbakht H, Zarei M, Gholamhosseini S, Djalali M (2015). Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad. Anadolu Kardiyoloji Dergisi, 15(12), 981-989.
Chicago	Ramezani A, Koohdani F, Djazayeri A, Nematipour E, Keshavarz SA, Sabooryaraghi AA, Eshraghian MR, et al.. "Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad." Anadolu Kardiyoloji Dergisi 15, no. 12 (2015): 981-989.
Harvard	Ramezani A et al. (2015) 'Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad', Anadolu Kardiyoloji Dergisi, 15(12), pp. 981-989.
Vancouver	Ramezani A, Koohdani F, Djazayeri A, Nematipour E, Keshavarz SA, Sabooryaraghi AA, et al.. Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad. Anadolu Kardiyoloji Dergisi. 2015;15(12):981-989.
BibTex	@article{ author = {Ramezani A and Koohdani F and Djazayeri A and Nematipour E and Keshavarz SA and Sabooryaraghi AA and Eshraghian MR and Yousefinejad A and Javanbakht H and Zarei M and Gholamhosseini S and Djalali M}, title = {Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad}, journal = {Anadolu Kardiyoloji Dergisi}, volume = {15}, number = {12}, pages = {981-989}, year = {2015} }
RIS	TY - JOUR AU - Ramezani A AU - Koohdani F AU - Djazayeri A AU - Nematipour E AU - Keshavarz SA AU - Sabooryaraghi AA AU - Eshraghian MR AU - Yousefinejad A AU - Javanbakht H AU - Zarei M AU - Gholamhosseini S AU - Djalali M TI - Effects of Administration of Omega-3 Fatty Acids With or Without Vitamin E Supplementation on Adiponectin Gene Expression in Pbmcs and Serum Adiponectin and Adipocyte Fatty Acid-Binding Protein Levels in Male Patients With Cad JO - Anadolu Kardiyoloji Dergisi VL - 15 IS - 12 SP - 981 EP - 989 PY - 2015 ER -

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