Omega-3 Fatty Acids/Vitamin E Behave Synergistically on Adiponectin Receptor-1 and Adiponectin Receptor-2 Gene Expressions in Peripheral Blood Mononuclear Cell of Coronary Artery Disease Patients



Ramezani A¹ ; Djazayeri A² ; Koohdani F¹ ; Nematipour E³ ; Javanbakht MH¹ ; Keshavarz SA⁴ ; Golalizadeh E⁵ ; Fard RMN⁶ ; Djalali M¹ Show Affiliations
Source: Current Topics in Nutraceutical Research Published:2015

Abstract

Reducing the levels of adiponectin receptors, AdipoRl and AdipoR2 can reduce the ability ofadiponectin in preventing inflammatory processes. Therefore, researches need to find a way to increase the gene expression of adiponectin receptors for the treatment of cardiovascular diseases. A randomized, double-blind, placebo controlled trial was conducted on 67 CAD male patients. Participants received 4glday ω3 plus 400IU/day vitamin E (OE) or 4gl day ω3plus vitamin Eplacebo (OP) or both ω3 and vitamin E placebos (PP) for two months. The Gene expression of diponectin receptors in PBMCs and serum high-sensitivity C-reactive protein in serum were measured. Consumption of omega-3 fatty acids significantly reduced the serum level of hsCRP as well as consumption of combined omega-3 fatty acids and vitamin E supplements. Gene expression of AdipoR2 significantly increased in OP and OE groups. Consumption of combined omega-3 fatty acids and vitamin E had a significant effect on the gene expression of AdipoRl. However, omega-3 fatty acids did not change the gene expression of AdipoRl significantly. Administration of omega-3 fatty acids with or without vitamin E for two months results in significant increases in the gene expression ofadiponectin receptors and hence improves serum levels of inflammatory process in CAD patients. © 2015 by New Century Health Publishers, LLC.