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Serum Il-33 Is Elevated in Children With Asthma and Is Associated With Disease Severity Publisher Pubmed



Bahrami Mahneh S1 ; Movahedi M2 ; Aryan Z2 ; Bahar MA1 ; Rezaei A3 ; Sadr M4 ; Rezaei N1, 3
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatrics Center of Excellence, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center Hospital, Iran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran
  4. 4. Stud's Scientific Research Center, Tehran University of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: International Archives of Allergy and Immunology Published:2016


Abstract

Background: The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. Objectives: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. Methods: This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated. Results: The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026). Conclusion: Serum IL-33 is increased in children with asthma and is associated with disease severity. © 2016 S. Karger AG, Basel.
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