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Circulating Micrornas in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers Publisher Pubmed



Mirzaei HR1 ; Sahebkar A2 ; Mohammadi M3 ; Yari R4 ; Salehi H5 ; Jafari MH6 ; Namdar A7 ; Khabazian E8 ; Jaafari MR9 ; Mirzaei H6
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Hepatitis Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Department of Biology, Faculty of Sciences, Boroujerd Branch, Islamic Azad University, Boroujerd, Iran
  5. 5. Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 91775-1365, Iran

Source: Current Pharmaceutical Design Published:2016


Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of malignancies worldwide. There is little information on the mechanisms involved in the pathogenesis of this disease. Diagnosis of HCC at early stages would be crucial for increasing the survival of patients. Circulating miRNAs have emerged as one of the most attractive tools for an early diagnosis of cancers. Various studies have shown that there is an aberrant expression of miRNAs such as miR-25, miR-375, miR-206, miR-223, miR-92a, miR-222, miR-1, let-7f and miR-21 in HCC. Circulating and tissue miRNAs have also key roles in the pathogenesis of HCC by affecting several biologically important pathways such as p53, p21, PTEN, PI3K-AKT, c-Myc and STAT3. In this review, we summarize the current knowledge on the role of miRNAs in diagnosis, prognosis, and treatment of HCC. © 2016 Bentham Science Publishers.
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