Artificial Intelligence-Assisted Design of Nanomedicines for Breast Cancer Diagnosis and Therapy: Advances, Challenges, and Future Directions Publisher



Shirzad M¹ ; Shaban M¹ ; Mohammadzadeh V¹ ; Rahdar A² ; Fathikarkan S^{3, 4} ; Hoseini ZS⁵ ; Najafi M⁶ ; Kharaba Z⁷ ; Aboudzadeh MA⁸ Show Affiliations
Source: BioNanoScience Published:2025

Abstract

This paper explores the revolutionary collaboration between artificial intelligence (AI) and nanotechnology in detecting and treating breast cancer. It highlights the synergistic potential of both fields to overcome significant limitations of modern approaches. Clinical applications and research demonstrate the diversity and depth of AI-based deep learning models in diagnostics, improving diagnostic accuracy and enabling precise, individualized therapy through advanced imaging and biomarker discovery. Through intelligent nanocarriers, nanotechnology contributes to these advancements by enabling targeted drug delivery, minimizing systemic toxicity, and providing theranostic capabilities for real-time monitoring. However, challenges remain, including data accessibility, model interpretability, scalability in nanocarrier manufacturing, and tumor diversity. Future improvements should focus on developing multifunctional nanoparticles, flexible AI algorithms, and scalable, cost-effective solutions to enhance accessibility and clinical integration. Hence, the study emphasizes the need for multidisciplinary collaboration to eliminate existing barriers and generate advancements to transform breast cancer therapies into more effective, safer, and individualized methods. © The Author(s) 2025.