The Role of Non-Coding Rnas in the Diagnosis of Different Stages (Hcc, Chb, Obi) of Hepatitis B Infection Publisher Pubmed



Gholizadeh O^{1, 2, 3} ; Akbarzadeh S⁴ ; Moein M⁴ ; Yasamineh S³ ; Hosseini P⁵ ; Afkhami H⁶ ; Amini P¹ ; Dadashpour M⁷ ; Tahavvori A⁸ ; Eslami M⁹ ; Hossein Taherian M¹⁰ ; Poortahmasebi V^{1, 2} Show Affiliations
Source: Microbial Pathogenesis Published:2023

Abstract

Despite the availability of an effective hepatitis B virus (HBV) vaccine and universal immunization schedules, HBV has remained a health problem in various stages such as occult hepatitis B infection (OBI), chronic hepatitis B (CHB), and hepatocellular carcinoma (HCC), which is considered one of the possible phases during chronic HBV infection. OBI is defined as the persistence of HBV genomes in hepatocytes of patients with a negative HBV surface antigen (HBsAg) test and detectable or undetectable HBV DNA in the blood. OBI is occasionally associated with infection caused by mutant viruses that produce a modified HBsAg that is undetected by diagnostic procedures or with replication-defective variations. Many aspects of HBV (OBI more than any other stage) including prevalence, pathobiology, and clinical implications has remained controversial. According to a growing body of research, non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been linked to the development and progression of a number of illnesses, including viral infectious disorders. Despite a shortage of knowledge regarding the expression and biological activities of lncRNAs and miRNAs in HBV infection, Hepatitis B remains a major global public health concern. This review summarizes the role of lncRNAs in the diagnosis and treatment of different stages of hepatitis B infection. © 2023