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Targeting Non-Apoptotic Cell Death in Cancer Treatment by Nanomaterials: Recent Advances and Future Outlook Publisher Pubmed



Sepand MR1 ; Ranjbar S2 ; Kempson IM3, 4 ; Akbariani M1 ; Muganda WCA5 ; Muller M5 ; Ghahremani MH1 ; Raoufi M2, 5
Authors
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Authors Affiliations
  1. 1. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia
  4. 4. School of Pharmacy and Medical Sciences, University of South Australia, SA, Australia
  5. 5. Physical Chemistry I and Research Center of Micro and Nanochemistry (Cμ), University of Siegen, Siegen, Germany

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2020


Abstract

Many tumors develop resistance to most of the apoptosis-based cancer therapies. In this sense targeting non-apoptotic forms of cell death including necroptosis, autophagy and ferroptosis may have therapeutic benefits in apoptosis-defective cancer cells. Nanomaterials have shown great advantages in cancer treatment owing to their unique characteristics. Besides, the capability of nanomaterials to induce different forms of cell death has gained widespread attention in cancer treatment. Reports in this field reflect the therapeutic potential of necroptotic cell death induced by nanomaterials in cancer. Also, autophagic cell death induced by nanomaterials alone and as a part of chemo-, radio- and photothermal therapy holds great promise as anticancer therapeutic option. Besides, ferroptosis induction by iron-based nanomaterials in drug delivery, immunotherapy, hyperthermia and imaging systems shows promising results in malignancies. Hence, this review is devoted to the latest efforts and the challenges in this field of research and its clinical merits. © 2020 Elsevier Inc.
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