Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Genetic Variant in Camkk2 Gene Is Possibly Associated With Increased Risk of Bipolar Disorder Publisher Pubmed



Atakhorrami M1 ; Rahimialiabadi S2 ; Jamshidi J3 ; Moslemi E1 ; Movafagh A2 ; Ohadi M4 ; Mirabzadeh A5 ; Emamalizadeh B2 ; Ghaedi H2 ; Gholipour F6 ; Fazeli A2 ; Motallebi M2 ; Taghavi S2 ; Ahmadifard A2 Show All Authors
Authors
  1. Atakhorrami M1
  2. Rahimialiabadi S2
  3. Jamshidi J3
  4. Moslemi E1
  5. Movafagh A2
  6. Ohadi M4
  7. Mirabzadeh A5
  8. Emamalizadeh B2
  9. Ghaedi H2
  10. Gholipour F6
  11. Fazeli A2
  12. Motallebi M2
  13. Taghavi S2
  14. Ahmadifard A2
  15. Mohammadihosseinabad S7
  16. Shafiei Zarneh AE2
  17. Shahmohammadibeni N8
  18. Madadi F2
  19. Andarva M2
  20. Darvish H2
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Basic Sciences, Islamic Azad University, East Tehran Branch (Ghiamdasht), Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  4. 4. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  5. 5. Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  6. 6. Department of Psychiatry, Emam Hossien Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Genetics, School of Medicine, Unit of Medical Sciences, Islamic Azad University, Tehran, Iran
  8. 8. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran

Source: Journal of Neural Transmission Published:2016


Abstract

A recent large-scale study have reported that rs1063843, a single nucleotide polymorphism located in the CAMKK2 gene is highly associated with schizophrenia in European and Han Chinese populations. Increasing evidences show that schizophrenia and bipolar disorder have some common genetic variance. Here, we evaluated the association of this variant with schizophrenia and bipolar disorder in Iranian population. Genomic DNA was extracted from peripheral blood of 500 schizophrenic patients, 500 bipolar patients and 500 normal controls and all were genotyped for the rs1063843 using a PCR–RFLP method. The allele frequency of rs1063843 was significantly different in both schizophrenia and bipolar patients comparing to control group. For the first time, we showed that rs1063843 is highly associated with bipolar disorder, although more replication studies are needed to confirm our findings. Our results also support the findings of previous studies suggesting a significant association between rs1063843 and schizophrenia. © 2015, Springer-Verlag Wien.
Related Docs
1. Snap-25 Gene Variations and Attention-Deficit Hyperactivity Disorder in Iranian Population, Neurological Research (2016)
2. Lrp8 (Rs5177) and Cep85l (Rs11756438) Are Contributed to Schizophrenia Susceptibility in Iranian Population, Psychiatric Genetics (2020)
3. Neuregulin-1 Gene and Schizophrenia, and Its Negative Symptoms in an Iranian Population, Iranian Journal of Psychiatry and Behavioral Sciences (2017)
4. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson’S and Alzheimer’S Diseases, Current Gene Therapy (2018)
5. Cortical Alpha Activity in Schizoaffective Patients, Iranian Journal of Psychiatry (2017)
Experts (# of related papers)
View all Related Experts
Esmaeil Shahsavand Ananloo (1)
Ehsan Aghaei-Moghadam (1)