Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Ank3 and Znf804a Intronic Variants Increase Risk of Schizophrenia in Iranian Population: An Association Study Publisher



Dashtban S1 ; Hajnasrolahfard F1 ; Kosari Z2 ; Ghamari R3 ; Forouzesh F1 ; Alizadeh F2
Authors

Source: Gene Reports Published:2022


Abstract

Background: Schizophrenia is a multifactorial psychiatric disorder with unknown etiology and prevalence of around 1% worldwide. ANK3 and ZNF804A are two most related genes with Schizophrenia and many psychiatric related phenotypes. Several studies have revealed the association of Schizophrenia with two intronic single nucleotide polymorphisms (SNPs) rs10761482 and rs7597593 lies within ANK3 and ZNF804A introns in several populations. But it wasn't confirmed in Iranian population up to now. Here, we aimed to explore the association of rs10761482 and rs7597593 with Schizophrenia in Iranian population. Methods: We genotyped 154 Schizophrenic patients and 154 healthy controls both with Iranian descent for rs10761482 and rs7597593 using ARMS-PCR. Genotypic frequency distribution, Odds Ratios, and Logistic regression were performed for statistical analysis. Results: Our results indicate that carrying T allele in both rs7597593 and rs10761482 is associated with Schizophrenia (rs10761482: p-valueChi-square = 0.007, OR(SCZ/control) = 1.943195/ rs7597593: p-valueChi-squared = 5.736 × 10−9, OR(SCZ/control) = 4.088313) and increases the risk of schizophrenia incidence in Iranian population (p-valuers759793 = 1.80 × 10−11, p-valuers10761482 = 6.09 × 10−5). Besides, affected males show more homozygosity in comparison with female patients (p-valueChi-squared = 0.03046, OR(male/female) = 2.203385). Conclusion: Our results confirmed that rs10761482 and rs7597593 significantly associated with schizophrenia in Iranian population and increase risk of the disease. Besides, we observed that rs10761482 and rs7597593 both increase the risk of Schizophrenia in our sample and with regard to their strong association, they could be a potential biomarker for predicting the risk of Schizophrenia in Iranian descent. © 2022
Related Docs
View other Related Docs
1. Polymorphism in the 3′-Utr of Lif But Not in the Atf6b Gene Associates With Schizophrenia Susceptibility: A Case-Control Study and in Silico Analyses, Journal of Molecular Neuroscience (2020)
2. Neuregulin-1 Gene and Schizophrenia, and Its Negative Symptoms in an Iranian Population, Iranian Journal of Psychiatry and Behavioral Sciences (2017)
3. Evaluation of the Possible Association of Znf804a Variant Rs7597593 With Bipolar Disorder in an Iranian Population, Gene Reports (2025)
Experts (# of related papers)
View all Related Experts
Esmaeil Shahsavand Ananloo (7)
Mahmoud Reza Hadjighassem (2)
Other Related Docs
4. Association Analysis of Disc1 Gene Polymorphisms With Attention-Deficit Hyperactivity Disorder in Iranian Population, Pakistan Journal of Medical Sciences (2015)
5. The Contribution of the 5-Hydroxytryptamine Receptor 2 A Gene Polymorphisms Rs6311 and Rs6313 to Schizophrenia in Iran, Molecular Biology Reports (2023)
6. Serotonin Transporter Functional Polymorphisms Potentially Increase Risk of Schizophrenia Separately and As a Haplotype, Scientific Reports (2022)
7. No Genetic Association Between A118g Polymorphism of Μopioid Receptor Gene and Schizophrenia and Bipolar Disorders, Indian Journal of Psychiatry (2017)
8. Tcf4 and Grm8 Gene Polymorphisms and Risk of Schizophrenia in an Iranian Population: A Case-Control Study, Molecular Biology Reports (2018)
9. Association Between Brain-Derived Neurotropic Factor Gene Variant (Rs6265; C > T) and Schizophrenia, Its Psychopathology and Intelligence, European Journal of Psychiatry (2021)
10. Disease-Only Alleles at the Extreme Ends of the Human Zmym3 Exceptionally Long 5′ Utr Short Tandem Repeat in Bipolar Disorder: A Pilot Study, Journal of Affective Disorders (2019)
11. Large-Scale Meta-Analysis of Tnf-Α Rs1800629 Polymorphism in Schizophrenia: Evidence From 7,624 Cases and 8,933 Controls; Sizofrenide Tnf-Α Rs1800629 Polimorfizminin Genis Olcekli Meta-Analizi: 7.624 Olgu Ve 8.933 Kontrolden Elde Edilen Kanitlar, Medeniyet Medical Journal (2025)
12. Association of Transcription Factor 4 (Tcf4) Gene Mrna Level With Schizophrenia, Its Psychopathology, Intelligence and Cognitive Impairments, Journal of Neurogenetics (2017)
13. Association Between Neuregulin-1 Gene Variant (Rs2439272) and Schizophrenia and Its Negative Symptoms in an Iranian Population, Iranian Journal of Psychiatry (2016)
14. Neuregulin1 Gene Variants As a Biomarker for Cognitive Impairments in Patients With Schizophrenia, European Journal of Psychiatry (2020)
15. Lrp8 (Rs5177) and Cep85l (Rs11756438) Are Contributed to Schizophrenia Susceptibility in Iranian Population, Psychiatric Genetics (2020)
16. Frequency of M287t/As3mt Single Nucleotide Polymorphism in an Iranian Population, International Journal of Hematology-Oncology and Stem Cell Research (2017)
17. Skewing of the Genetic Architecture at the Zmym3 Human-Specific 5′ Utr Short Tandem Repeat in Schizophrenia, Molecular Genetics and Genomics (2018)
18. Association Study of Aff1 Gene Polymorphism (Rs340630) With Iranian Systemic Lupus Erythematosus Patients, Acta Reumatologica Portuguesa (2016)
19. An Integrative Gene Network-Based Approach to Uncover the Cellular and Molecular Infrastructures of Schizophrenia, Life Sciences (2020)
20. A Genetic Variant in Camkk2 Gene Is Possibly Associated With Increased Risk of Bipolar Disorder, Journal of Neural Transmission (2016)