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Neuregulin-1 Gene and Schizophrenia, and Its Negative Symptoms in an Iranian Population Publisher



Hatami M1 ; Karamghadiri N1 ; Mohaghegh H2 ; Yoosefee S3 ; Karimipoor M4 ; Hadjighasem M2, 5 ; Ananloo ES1
Authors
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Authors Affiliations
  1. 1. Department of Genomic Psychiatry and Behavioral Genomics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran
  4. 4. Pasteur Institute of Iran, Tehran, Iran
  5. 5. Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Psychiatry and Behavioral Sciences Published:2017


Abstract

Background: During the last two decades, mucheffort is put to better understand the etiology of schizophrenia. Studying negative symptoms such as endophenotypes is a plausible approach to elucidate the genetic basis of schizophrenia. Neuregulin-1 (NRG1) is a key candidate gene to develop schizophrenia and its negative symptoms. The NRG1 variant rs6988339 was previously characterized as a schizophrenia susceptibility locus in different Scottish populations. Objectives: The current study aimed to examine the association of rs6988339 with schizophrenia and its negative symptoms in an Iranian population. Methods: The current case-controlled study enrolled 469 subjects (276 unrelated schizophrenia patients and 193 healthy controls). The study investigated the association of rs6988339 with schizophrenia and its negative symptoms (assessed with the positive and negative syndrome scale; PANSS) in an Iranian population. Results: The obtained results showed that rs6988339 was a schizophrenia susceptibility locus in the Iranian population, the minor allele G was the risk allele and A the protective allele (P = 0.0007). Of the four subscales of the PANSS test, the negative score showed the strongest association with this variant (P = 0.001). Conclusions: The results further supported the implication of NRG1 in the pathogenesis of negative symptoms in schizophrenia. © 2017, Iranian Journal of Psychiatry and Behavioral Sciences.
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