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New Insight to Il-23/Il-17 Axis in Iranian Infected Adult Patients With Gastritis : Effects of Genes Polymorphisms on Expression of Cytokines Pubmed



Shirzad H1 ; Bagheri N2 ; Azadegandehkordi F1 ; Zamanzad B1 ; Izadpanah E3 ; Abdi M4 ; Ramazani G5 ; Sanei MH6 ; Ayoubian H7 ; Ahmadi A8 ; Jamalzehi S9 ; Aslani P8 ; Zandi F8
Authors
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Authors Affiliations
  1. 1. Cellular & Molecular Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
  2. 2. Department of Immunology, School of Public Health, Teheran University of Medical Sciences, Teheran, Iran
  3. 3. Departments of Physiology and Pharmacology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Department of Clinical Biochemistry, Kurdistan University of Medical Sciences, Sanandaj, Iran
  5. 5. Endoscopy Department of Hajar hospital, Shahrekord University of Medical Sciences, Shahrkord, Iran
  6. 6. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. University of Saarland, Saaraland, Germany
  8. 8. Kurdistan Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  9. 9. Department of immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Acta Gastro-Enterologica Belgica Published:2015


Abstract

Background and Objective : Chronic inflammation is the hallmark of the pathogenesis of H. pylori-induced gastric cancer. IL-17A and IL-17F are inflammatory cytokines expressed by a novel subset of CD4+Th cells and play critical function in inflammation. We evaluated the relationship between IL-17A G197A, IL-17F A7488G and IL23R+2199 A/C polymorphisms with IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression in regard to H. pylori infection with chronic gastritis. Materials and Methods : Total RNA and genomic DNA were extracted from gastric biopsies of 58 H. pylori-infected patient with gastritis. Afterward, mucosal IL-6, IL-17, IL-21, IL-23 and TGF-β1 mRNAs expression and polymorphisms in IL-17A G197A, IL-17F A7488G and IL-23R +2199A/Cin gastric biopsies were determined by real-time PCR and PCR-RFLP. Results : Our results show that IL-17A G197A, IL-17F A7488G andIL23R +2199A/C polymorphisms have no effect on mucosal expression of IL-6, IL-17, IL-21 and TGF-β1 mRNAs expression in H. pylori-infected patients with chronic gastritis. Conclusion : These results suggest that IL-17A G197A, IL-17F A7488G and IL23R +2199A/C polymorphisms no alter mucosal cytokine pattern in Iranian patients with H. pylori-associated gastritis diseases. © 2015, Universa Press.
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