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Distinctive Expression Pattern of Interleukin-17 Cytokine Family Members in Colorectal Cancer Publisher Pubmed



Alsamadi A1, 2 ; Moossavi S3 ; Salem A1 ; Sotoudeh M5 ; Tuovinen SM1 ; Konttinen YT1, 6, 7 ; Salo T2 ; Bishehsari F8
Authors
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Authors Affiliations
  1. 1. Department of Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland
  2. 2. Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
  3. 3. Digestive Oncology Research Center
  4. 4. Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, North Amirabad Ave., Tehran, 14117, Iran
  5. 5. Pathology Department, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
  7. 7. ORTON Orthopedic Hospital of the Invalid Foundation, Helsinki, Finland
  8. 8. Division of Digestive Diseases, Rush University Medical Center, Chicago, IL, United States

Source: Tumor Biology Published:2016


Abstract

Colorectal cancer (CRC) is one of the most common cancers in both genders. Even though interleukin (IL)-17A was shown to play an important role in intestinal tumourigenesis and CRC, other IL-17 family members were not studied well. We therefore studied the expression of IL-17 cytokine family members in CRC. Ten healthy colons and ten CRC mucosa were immunostained for IL-17B, IL-17C, IL-17E, and IL-17F, and their receptors IL-17RA, IL-17RB, and IL-17RC. Double immunofluorescence staining of the CRC mucosa was done for IL-17B with markers of neutrophils, endothelial cells, macrophages, T cells, mast cells, or fibroblasts. While IL-17B was increased in CRC with a strong presence both in the epithelial and stromal compartments, IL-17C showed different expression depending on the grade of differentiation and IL-17E remained unchanged. In contrast, IL-17F was decreased in CRC compared to healthy control. Colon epithelial cells stained positive for IL-17RA, IL-17RB, and IL-17RC in both healthy control and CRC. Neutrophils were the main source of IL-17B in the stroma. IL-17 family members demonstrated distinct expression patterns in CRC, suggesting a differential role exerted by each member in colon carcinogenesis. © 2015, International Society of Oncology and BioMarkers (ISOBM).
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