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The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells Into Mesodermal Lineage Publisher Pubmed



Gorabi AM1 ; Kiaie N1 ; Hajighasemi S2 ; Jamialahmadi T3, 4 ; Majeed M5 ; Sahebkar A6, 7, 8
Authors

Source: Molecules Published:2019


Abstract

Curcumin has been placed at the forefront of the researcher's attention due to its pleiotropic pharmacological effects and health benefits. A considerable volume of articles has pointed out curcumin's effects on the fate of stem cell differentiation. In this review, a descriptive mechanism of how curcumin affects the outcome of the differentiation of mesenchymal stem cells (MSCs) into the mesodermal lineage-i.e., adipocyte, osteocyte, and chondrocyte differentiation-is compiled from the literature. The sections include the mechanism of inhibition or induction of MSCs differentiation to each lineage, their governing molecular mechanisms, and their signal transduction pathways. The effect of different curcumin doses and its structural modifications on the MSCs differentiation is also discussed. © 2019 by the authors.
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