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Thermodynamic Studies on Calixarene Nanoparticles As a Carrier and Adsorbent of Mercaptopurine Anticancer Drug in Drug Delivery Using Experimental Methods Publisher



Karamjavan MM1 ; Zare K1 ; Sefidan AM2 ; Noei M3 ; Farajtabar A4
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Department of Chemistry, Faculty of Sciences, Jouybar Branch, Islamic Azad University, Jouybar, Iran

Source: Russian Journal of Physical Chemistry A Published:2022


Abstract

Abstract: Calix[4]arene refers to a group of large cyclic compounds involving a sequence of phenols, which are obtained through the hydroxylation reaction process of phenol and aldehyde derivatives. Calixarenes have a rigid and three-dimensional structure. Nanoparticles can be used in drug delivery due to their ability to enter cells. The application of a carrier for drug delivery is very effective on improving their performance. In order to employ calixarene nanoparticles as the carriers of mercaptopurine drug, their ability and type of adsorption were examined on laboratory scale. In this study, by examining the temperature changes on the course of adsorption and by matching the data against Langmuir adsorption isotherm, Freundlich, and Dubinin–Radushkevich, the numbers of all thermodynamic constants of this process were calculated. The obtained adsorption capacities indicated that the elevation of the initial concentration leads to the enhanced adsorption capacity. Moreover, by considering the obtained thermodynamic constants, it was found that the adsorption process is exothermic, while the values of Gibbs free energy ∆G0 and the adsorption energy Ea showed that the adsorption process was spontaneous and chemical. © 2022, Pleiades Publishing, Ltd.