Brown Adipose Tissue Transplantation As a Novel Alternative to Obesity Treatment: A Systematic Review Publisher Pubmed



Payab M¹ ; Abedi M² ; Foroughi Heravani N² ; Hadavandkhani M² ; Arabi M² ; Tayanloobeik A² ; Sheikh Hosseini M³ ; Gerami H⁴ ; Khatami F⁵ ; Larijani B⁴ ; Abdollahi M^{4, 6} ; Arjmand B^{2, 3} Show Affiliations
Source: International Journal of Obesity Published:2021

Abstract

Background: Obesity, a global challenge, is a complex disorder linked to various diseases. Different kinds of treatments are currently used to treat or control this pandemic. Despite their positive effects on controlling obesity, they still have limitations and side effects including digestive problems, difficulties of daily infusion of some drugs, surgical complications, and weight regain. All these issues cause these conventional methods not to have desirable efficacy. In this regard, brown adipose tissue (BAT) transplantation as a new investigational treatment is proposed, which has beneficial effects with no documented side effect in studies up to now. Methods: This systematic review protocol was registered in the International Prospective Register of Systematic Reviews (Registration Number: CRD42018110045). The systematical search was conducted on Web of Science, Scopus, PubMed, Embase, and ProQuest databases. The quality assessments in the included studies and data gathering were conducted independently by two authors. The main variables were anthropometric indices including body weight, levels of leptin, IGF-1, glucagon, adiponectin, fasting blood glucose, and UCP-1. Results: Following the search in mentioned databases, ten articles were entered into this systematic review. In most studies, weight gain and white adipocyte size were reduced in the BAT transplant group. It seems that the transplantation leads to the regeneration of healthy adipose tissue by activating the endogenous BAT. Conclusions: Since BAT transplantation is one of the possible future treatments of obesity, many studies are conducted to evaluate the outcomes and related procedures precisely, so it can finally step into clinical application. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.