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Influence of Functionalised Multiwalled Carbon Nanotubes With Imidazole Derivative and Thiosemicarbazide on Mkn45 and Sw742 Cancer Cells Publisher



Tahermansouri H1 ; Abedi E1 ; Heidarikeshel S2 ; Tarlani A3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
  2. 2. Stem Cell Preparation Unit, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Inorganic Nanostructures and Catalysts Research Laboratory, Chemistry and Chemical Engineering Research Center of Iran, Pajoohesh Boulevard, Tehran, 14968-13151, Iran

Source: Materials Technology Published:2015


Abstract

Carboxylated multiwall carbon nanotubes (MWCNT-COOH) were first modified by an imidazole derivative, 2-amino-1-methyl-5-(3,4,5-trimethoxybenzylidene)-1H-imidazol-4(5H)-one, to form a MWCNT-Im and then by thiosemicarbazide to produce MWCNT-Py. All products were characterised by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, energy dispersive X-ray spectroscopy, solubility test, thermogravimetric analysis, derivative thermogravimetric and cellular investigations. These functionalisations have been chosen due to active sites of C5C and carbonyl groups in MWCNT-Im and NH2 and sulphur groups in MWCNT-Py, which might be used as functional materials in future. Toxicity of these samples was evaluated with human gastric (MKN45) and colon (SW742) cancer cells, and the killed cell numbers were measured by reduction in living cells with 3-(4,5-dimethyl-2-thiazolyl)- 2,5-diphenyltetrazolium bromide (MTT) after 48 h of cell culture experiments. Cellular investigations showed high toxicity of modified MWCNTs on the gastric cancer cells compared to colon cells. In addition, MWCNT-Py sample indicated the highest toxicity for both cancer cells compared to other samples. © 2015 W. S. Maney & Son Ltd.
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